Enzymes Recombinant Proteins

Human CTSW Recombinant Protein (RPPB1524)

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SKU:
RPPB1524
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P56202
Research Area:
Enzymes

Description

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Product Name:Human CTSW Recombinant Protein
Product Code:RPPB1524
Size:20µg
Species:Human
Target:CTSW
Synonyms:Cathepsin W (Lymphopain), LYPN, lymphopain, EC 3.4.22.-.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The CTSW solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSIRGPLRA QDLGPQPLEL KEAFKLFQIQ FNRSYLSPEE HAHRLDIFAH NLAQAQRLQE EDLGTAEFGV TPFSDLTEEE FGQLYGYRRA AGGVPSMGRE IRSEEPEESV PFSCDWRKVA GAISPIKDQK NCNCCWAMAA AGNIETLWRI SFWDFVDVSV QELLDCGRCG DGCHGGFVWD AFITVLNNSG LASEKDYPFQ GKVRAHRCHP KKYQKVAWIQ DFIMLQNNEH RIAQYLATYG PITVTINMKP LQLYRKGVIK ATPTTCDPQL VDHSVLLVGF GSVKSEEGIW AETVSSQSQP QPPHPTPYWI LKNSWGAQWG EKGYFRLHRG SNTCGITKFP LTARVQKPDM KPRVSCPP

CTSW protein belongs to the peptidase C1 family. CTSW is a cysteine proteinase with a detailed role in the regulation and mechanism of T-cell cytolytic activity. The encoded CTSW is linked to the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. CTSW expression is up-regulated by interleukin-2.

CTSW Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 378 amino acids (22-376) and having a molecular mass of 42.0 kDa. CTSW is fused to a 23 amino acid His-tag at N-terminus.

UniProt Protein Function:CTSW: May have a specific function in the mechanism or regulation of T-cell cytolytic activity. Belongs to the peptidase C1 family.
UniProt Protein Details:

Protein type:Protease; EC 3.4.22.-

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: membrane

Molecular Function:cysteine-type peptidase activity

Biological Process: immune response; proteolysis

NCBI Summary:The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]
UniProt Code:P56202
NCBI GenInfo Identifier:23110964
NCBI Gene ID:1521
NCBI Accession:NP_001326.2
UniProt Secondary Accession:P56202,Q86VT4,
UniProt Related Accession:P56202
Molecular Weight:42,120 Da
NCBI Full Name:cathepsin W preproprotein
NCBI Synonym Full Names:cathepsin W
NCBI Official Symbol:CTSW��
NCBI Official Synonym Symbols:LYPN��
NCBI Protein Information:cathepsin W; lymphopain
UniProt Protein Name:Cathepsin W
UniProt Synonym Protein Names:Lymphopain
Protein Family:Cathepsin
UniProt Gene Name:CTSW��
UniProt Entry Name:CATW_HUMAN
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