Enzymes Recombinant Proteins

Human CTSS Recombinant Protein (RPPB1522)

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SKU:
RPPB1522
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P25774
Research Area:
Enzymes

Description

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Product Name:Human CTSS Recombinant Protein
Product Code:RPPB1522
Size:20µg
Species:Human
Target:CTSS
Synonyms:Cathepsin S, MGC3886, CTSS, Cathepsin-S.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CTSS solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MQLHKDPTLD HHWHLWKKTY GKQYKEKNEE AVRRLIWEKN LKFVMLHNLE HSMGMHSYDL GMNHLGDMTS EEVMSLMSSL RVPSQWQRNI TYKSNPNWIL PDSVDWREKG CVTEVKYQGS CGACWAFSAV GALEAQLKLK TGKLVSLSAQ NLVDCSTEKY GNKGCNGGFM TTAFQYIIDN KGIDSDASYP YKAMDQKCQY DSKYRAATCS KYTELPYGRE DVLKEAVANK GPVSVGVDAR HPSFFLYRSG VYYEPSCTQN VNHGVLVVGY GDLNGKEYWL VKNSWGHNFG EEGYIRMARN KGNHCGIASF PSYPEI

Cathepsin S (CTSS) belongs to the peptidase C1 family. CTSS is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS functions as an elastase over a broad pH range in alveolar macrophages.

CTSS Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 336 amino acids (17-331) and having a molecular mass of 38.1kDa. CTSS is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.�

UniProt Protein Function:CTSS: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protease; EC 3.4.22.27

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular region; extracellular space; intracellular membrane-bound organelle; lysosomal lumen; lysosome

Molecular Function:collagen binding; cysteine-type endopeptidase activity; fibronectin binding; laminin binding; proteoglycan binding; serine-type endopeptidase activity

Biological Process: adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen; collagen catabolic process; extracellular matrix disassembly; immune response; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process; response to acidity; toll-like receptor signaling pathway

NCBI Summary:The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:P25774
NCBI GenInfo Identifier:88984046
NCBI Gene ID:1520
NCBI Accession:P25774.3
UniProt Secondary Accession:P25774,Q5T5I0, Q6FHS5, Q9BUG3, B4DWC9, D3DV05,
UniProt Related Accession:P25774
Molecular Weight:31,626 Da
NCBI Full Name:Cathepsin S
NCBI Synonym Full Names:cathepsin S
NCBI Official Symbol:CTSS��
NCBI Protein Information:cathepsin S
UniProt Protein Name:Cathepsin S
Protein Family:Cathepsin
UniProt Gene Name:CTSS��
UniProt Entry Name:CATS_HUMAN
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