Human CTNNBIP1 Recombinant Protein (RPPB3308)
- SKU:
- RPPB3308
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NSA3
Description
| Product Name: | Human CTNNBIP1 Recombinant Protein |
| Product Code: | RPPB3308 |
| Size: | 25µg |
| Species: | Human |
| Target: | CTNNBIP1 |
| Synonyms: | ICAT, MGC15093, CNBP1, CTNNBIP1, Beta-catenin-interacting protein 1, Inhibitor of beta-catenin and Tcf-4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CTNNBIP1 Human solution containing 20mM Tris-HCl pH-7.5, 2mM DTT, 0.1M NaCl & 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q |
CTNNBIP1 binds CTNNB1 and avoids interaction between CTNNB1 and TCF (T-cell transcription factor) family members. CTNNBIP1 is a negative regulator of the Wnt signaling pathway.
CTNNBIP1 Recombinant E.coli produced in E.Coli is a single, non-glycosylated polypeptide chain containing 101 amino acids (1-81 a.a.) and having a molecular mass of 11.3 kDa. The CTNNBIP1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CTNNBIP1: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Belongs to the CTNNBIP1 family. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Inhibitor Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: nucleoplasm; cytoplasm; nucleus; beta-catenin destruction complex; cytosol Molecular Function:protein binding; beta-catenin binding Biological Process: anterior/posterior pattern formation; positive regulation of monocyte differentiation; positive regulation of osteoblast differentiation; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; ureteric bud branching; negative regulation of smooth muscle cell proliferation; negative regulation of transcription factor activity; negative regulation of protein binding; regulation of vascular permeability during acute inflammatory response; negative regulation of DNA binding |
| NCBI Summary: | The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NSA3 |
| NCBI GenInfo Identifier: | 59889555 |
| NCBI Gene ID: | 56998 |
| NCBI Accession: | NP_001012329.1 |
| UniProt Secondary Accession: | Q9NSA3,Q9JJN6, |
| UniProt Related Accession: | Q9NSA3 |
| Molecular Weight: | 9,170 Da |
| NCBI Full Name: | beta-catenin-interacting protein 1 |
| NCBI Synonym Full Names: | catenin, beta interacting protein 1 |
| NCBI Official Symbol: | CTNNBIP1�� |
| NCBI Official Synonym Symbols: | ICAT�� |
| NCBI Protein Information: | beta-catenin-interacting protein 1; beta-catenin-interacting protein ICAT; inhibitor of beta-catenin and Tcf-4 |
| UniProt Protein Name: | Beta-catenin-interacting protein 1 |
| UniProt Synonym Protein Names: | Inhibitor of beta-catenin and Tcf-4 |
| UniProt Gene Name: | CTNNBIP1�� |
| UniProt Entry Name: | CNBP1_HUMAN |
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