Immune Checkpoint Recombinant Proteins
Human CTLA-4 Recombinant Protein (mFc-His Tag) (HDPT0017)
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- SKU:
- HDPT0017
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immune Checkpoint
Description
Human CTLA-4 Recombinant Protein (mFc-His Tag)
| Description: | This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. |
| Product name: | Human CTLA-4 Recombinant Protein (mFc-His Tag) |
| Synonyms: | CTLA4, CD152 |
| Type: | protein |
| Size: | 50 µg |
| Name: | CTLA-4 |
| Origin: | Human |
| Source: | HEK293 |
| Protein Type: | Recombinant |
| Application: | ELISA, Flow Cyt |
| Purity: | > 95% |
| Purification: | affinity purification |
| Format: | Lyophilized |
| Conjugate: | C-Mouse Fc and 6×His tag |
| Storage: | Store at -80°C for 12 months (Avoid repeated freezing and thawing) |
| Usage: | Research use only |
| Buffer: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. |
| Reconstitution: | Reconstitute with deionized water |
| Sequence: | CTLA-4（Gln36-Ser161）+mFc（Pro99-Lys330）+6×His |
| Gene ID: | 1493 |
| Uniprot: | P16410 |
| Molecular Weight: | 54 kDa |
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