Immune Checkpoint Recombinant Proteins

Human CTLA-4 Recombinant Protein (mFc-His Tag) (HDPT0017)

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SKU:
HDPT0017
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immune Checkpoint

Description

Human CTLA-4 Recombinant Protein (mFc-His Tag)

Description:This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Product name:Human CTLA-4 Recombinant Protein (mFc-His Tag)
Synonyms:CTLA4, CD152
Type:protein
Size:50 µg
Name:CTLA-4
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:ELISA, Flow Cyt
Purity:> 95%
Purification:affinity purification
Format:Lyophilized
Conjugate:C-Mouse Fc and 6×His tag
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:CTLA-4(Gln36-Ser161)+mFc(Pro99-Lys330)+6×His
Gene ID:1493
Uniprot:P16410
Molecular Weight:54 kDa
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