Immune Checkpoint Recombinant Proteins

Human CTLA-4 Recombinant Protein (hFc Tag) (HDPT0091)

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SKU:: HDPT0091
UPC:
MPN:
Product Type:: Recombinant Protein
Species:: Human
Research Area:: Immune Checkpoint

Description
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Description

Human CTLA-4 Recombinant Protein (hFc Tag)

Description:	This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Product name:	Human CTLA-4 Recombinant Protein (hFc Tag)
Synonyms:	CTLA4, CD152
Type:	protein
Size:	50 µg
Name:	CTLA-4
Origin:	Human
Source:	HEK293
Protein Type:	Recombinant
Application:	Flow Cyt
Purity:	> 95%
Purification:	affinity purification
Format:	Lyophilized
Conjugate:	C-Human Fc
Storage:	Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:	Research use only
Buffer:	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:	Reconstitute with deionized water
Sequence:	CTLA-4（Gln36-Ser161）+hFc（Glu99-Ala330）
Gene ID:	1493
Uniprot:	P16410
Molecular Weight:	39.6 kDa