Human CTHRC1 Recombinant Protein (RPPB3306)
- SKU:
- RPPB3306
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96CG8
Description
| Product Name: | Human CTHRC1 Recombinant Protein |
| Product Code: | RPPB3306 |
| Size: | 10µg |
| Species: | Human |
| Target: | CTHRC1 |
| Synonyms: | Collagen Triple Helix Repeat Containing 1, Protein NMTC1, CTHRC1. |
| Source: | HEK293 Cells |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | CTHRC1 was filtered (0.4�m) and lyophilized in phosphate buffered saline pH 7.5. |
| Solubility: | It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. CTHRC1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | SEIPKGKQKA QLRQREVVDL YNGMCLQGPA GVPGRDGSPG ANGIPGTPGI PGRDGFKGEK GECLRESFEE SWTPNYKQCS WSSLNYGIDL GKIAECTFTK MRSNSALRVL FSGSLRLKCR NACCQRWYFT FNGAECSGPL PIEAIIYLDQ GSPEMNSTIN IHRTSSVEGL CEGIGAGLVD VAIWVGTCSD YPKGDASTGW NSVSRIIIEE LPK HHHHHH |
Collagen triple helix repeat-containing protein 1 (CTHRC1) functions as a negative regulator of collagen matrix deposition. CTHRC1 is a secreted 28kDa protein which is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 is highly connected with calcified tissues and cartilaginous matrix, but not with endothelial cells. CTHRC1 is detected qualitatively in plasma of healthy human subjects. CTHRC1 plasma levels are also significantly elevated during pregnancy, in diabetes, in inflammatory and infectious conditions, in subjects with acute myeloid leukemia but not in subjects with solid cancers. The hormonal functions of CTHRC1 include regulation of lipid storage and cellular glycogen levels with potentially far-reaching implications for cell metabolism and physiology. CTHRC1 gene deletion leads to fatty liver (steatosis) formation in mice while others exhibited inactivation of the CTHRC1 gene also results in low bone mass.
CTHRC1 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Ser31-Lys243) containing a total of 219 amino acids, having a calculated molecular mass of 23.9kDa and fused to a 6 aa His tag at C-Terminus.
| UniProt Code: | Q96CG8 |
| NCBI GenInfo Identifier: | 19923989 |
| NCBI Gene ID: | 115908 |
| NCBI Accession: | NP_612464.1 |
| UniProt Secondary Accession: | Q96CG8,Q6UW91, Q8IX63, |
| UniProt Related Accession: | Q96CG8 |
| Molecular Weight: | 26,224 Da |
| NCBI Full Name: | collagen triple helix repeat-containing protein 1 |
| NCBI Synonym Full Names: | collagen triple helix repeat containing 1 |
| NCBI Official Symbol: | CTHRC1�� |
| NCBI Official Synonym Symbols: | CTHRC1�� |
| NCBI Protein Information: | collagen triple helix repeat-containing protein 1; OTTHUMP00000227821; OTTHUMP00000227823 |
| UniProt Protein Name: | Collagen triple helix repeat-containing protein 1 |
| UniProt Synonym Protein Names: | Protein NMTC1 |
| Protein Family: | Collagen triple helix repeat-containing protein |
| UniProt Gene Name: | CTHRC1�� |
| UniProt Entry Name: | CTHR1_HUMAN |
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