Enzymes Recombinant Proteins

Human CSNK1D Recombinant Protein (RPPB2492)

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SKU:
RPPB2492
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P48730
Research Area:
Enzymes

Description

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Product Name:Human CSNK1D Recombinant Protein
Product Code:RPPB2492
Size:20µg
Species:Human
Target:CSNK1D
Synonyms:Casein kinase I isoform delta, CKI-delta, CKId, Tau-protein kinase CSNK1D, CSNK1D, HCKID, delta isoform 2, Casein Kinase 1 Delta, Casein kinase 1.
Source:Escherichia Coli
Physical Appearance:CSNK1D is supplied as a sterile filtered clear solution.
Formulation:The CSNK1D solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQN SIPFEHHGK

Casein kinase I gene family members take part in the control of cytoplasmic and nuclear processes, including DNA replication and repair. Casein Kinase 1 Delta (CSNK1D) is a member of the casein kinase I (CKI) gene family. CSNK1D is a vital serine/threonine-protein kinase which regulates diverse cellular growth and survival processes including Wnt signaling and circadian rhythms. CSNK1D phosphorylates a great amount of proteins.

CSNK1D Human Recombinant produced in E. coli is a single polypeptide chain containing 429 amino acids (1-409) and having a molecular mass of 48.9kDa.CSNK1D is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CK1D: an ubiquitous protein kinase of the CK1 family. Enriched at the centrosomes in interphase and at the spindle during mitosis. May play a role in cell cycle progression. Two splice variant isoforms have been described.
UniProt Protein Details:

Protein type:Protein kinase, CK1; EC 2.7.11.26; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: centrosome; cytosol; ER-Golgi intermediate compartment membrane; Golgi apparatus; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; spindle; spindle microtubule

Molecular Function:protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: circadian regulation of gene expression; COPII coating of Golgi vesicle; DNA repair; endocytosis; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis; microtubule nucleation; peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; protein localization in Golgi apparatus; regulation of cell shape; regulation of circadian rhythm; rRNA processing; sensory cilium biogenesis; signal transduction; spindle assembly

Disease: Advanced Sleep Phase Syndrome, Familial, 2

NCBI Summary:This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
UniProt Code:P48730
NCBI GenInfo Identifier:27923980
NCBI Gene ID:1453
NCBI Accession:P48730.2
UniProt Secondary Accession:P48730,Q96KZ6, Q9BTN5, A2I2P2,
UniProt Related Accession:P48730
Molecular Weight:46,832 Da
NCBI Full Name:Casein kinase I isoform delta
NCBI Synonym Full Names:casein kinase 1 delta
NCBI Official Symbol:CSNK1D��
NCBI Official Synonym Symbols:ASPS; HCKID; FASPS2; CKIdelta��
NCBI Protein Information:casein kinase I isoform delta
UniProt Protein Name:Casein kinase I isoform delta
UniProt Synonym Protein Names:Tau-protein kinase CSNK1D (EC:2.7.11.26)
Protein Family:Casein kinase
UniProt Gene Name:CSNK1D��
UniProt Entry Name:KC1D_HUMAN
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