Growth Factors & Cytokines Recombinant Proteins

Human CSF2RA Recombinant Protein (RPPB0136)

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SKU:
RPPB0136
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P15509
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human CSF2RA Recombinant Protein
Product Code:RPPB0136
Size:20µg
Species:Human
Target:CSF2RA
Synonyms:CD116, CDw116, CSF2R, GM-CSF-R-alpha, GMCSFR, GMR, SMDP4,GMR-alpha, CD116 Antigen, CSF2RAX, CSF2RY, CSF2RAY, CSF2RX, Colony StimulatingFactor 2 Receptor Alpha Subunit, GM-CSF Receptor Alpha Subunit, Granulocyte-MacrophageColony-Stimulating Factor Receptor Alpha Chain, Granulocyte-MacrophageColony-Stimulating Factor Receptor Subunit Alpha.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:CSF2RA protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 85.0% as determined by SDS-PAGE.

GM-CSFReceptor Alpha (CSF2RA) is the alpha subunit of the heterodimeric receptor forcolony stimulating factor 2, a cytokine which controls the production,differentiation, and function of granulocytes and macrophages. CSFR2 is also amember of the cytokine family of receptors. In addition, this gene is found inthe pseudoautosomal region (PAR) of the X and Y chromosomes. Multipletranscript variants encoding various isoforms have been found for this gene, whilesome of the isoforms being membrane-bound and others being soluble. Diseasesassociated with CSF2RA include surfactant metabolism dysfunction, pulmonary 4,and csf2ra-related pulmonary surfactant metabolism dysfunction.

CSF2RA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 324 amino acids (20-320 a.a) and having a molecular mass of 37.2kDa.CSF2RA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3

Cellular Component: extracellular region; integral to plasma membrane; intracellular; plasma membrane

Molecular Function:granulocyte colony-stimulating factor binding; granulocyte colony-stimulating factor receptor activity; protein binding; receptor activity

Biological Process: activation of MAPKK activity; axon guidance; cellular protein metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4

NCBI Summary:The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
UniProt Code:P15509
NCBI GenInfo Identifier:121509
NCBI Gene ID:1438
NCBI Accession:P15509.1
UniProt Secondary Accession:P15509,O00207, Q14429, Q14430, Q14431, Q16564, A7J003 A8KAM1, B4DW68, J3JS76, J3JS77,
UniProt Related Accession:P15509
Molecular Weight:31,101 Da
NCBI Full Name:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
NCBI Synonym Full Names:colony stimulating factor 2 receptor alpha subunit
NCBI Official Symbol:CSF2RA��
NCBI Official Synonym Symbols:GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha��
NCBI Protein Information:granulocyte-macrophage colony-stimulating factor receptor subunit alpha
UniProt Protein Name:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
UniProt Synonym Protein Names:CDw116; CD_antigen: CD116
Protein Family:Granulocyte-macrophage colony-stimulating factor receptor
UniProt Gene Name:CSF2RA��
UniProt Entry Name:CSF2R_HUMAN
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