Human CRYGN Recombinant Protein (RPPB3271)
- SKU:
- RPPB3271
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8WXF5
Description
| Product Name: | Human CRYGN Recombinant Protein |
| Product Code: | RPPB3271 |
| Size: | 20µg |
| Species: | Human |
| Target: | CRYGN |
| Synonyms: | Gamma-crystallin N, Gamma-N-crystallin, CRYGN. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CRYGN protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAQRSG KITLYEGKHF TGQKLEVFGD CDNFQDRGFM NRVNSIHVES GAWVCFNHPD FRGQQFILEH GDYPDFFRWN SHSDHMGSCR PVGMHGEHFR LEIFEGCNFT GQCLEFLEDS PFLQSRGWVK NCVNTIKVYG DGAAWSPRSF GAEDFQLSSS LQSDQGPEEA TTKPATTQPP FLTANL |
Crystallin gamma N (CRYGN) is a member of the Crystallins family. Crystallins are the main proteins of the vertebrate eye lens, where they preserve the transparency and refractive index of the lens. CRYGN is unique in the way that it has both beta and gamma crystallin protein motifs. The CRYGN is differentially controlled after early development, and is involved in cataract creation due to either age-related protein degradation or genetic mutation.
CRYGN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 206 amino acids (1-182 a.a) and having a molecular mass of 23.1kDa.CRYGN is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CRYGN: The beta and gamma crystallins are evolutionarily related families of proteins that are localized to the refractive structure of the eye lens. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 7q36.1 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| UniProt Code: | Q8WXF5 |
| NCBI GenInfo Identifier: | 815891370 |
| NCBI Gene ID: | 155051 |
| NCBI Accession: | NP_001295221.1 |
| UniProt Secondary Accession: | Q8WXF5,Q496G6 |
| UniProt Related Accession: | Q8WXF5 |
| Molecular Weight: | 14,224 Da |
| NCBI Full Name: | gamma-crystallin N isoform b |
| NCBI Synonym Full Names: | crystallin gamma N |
| NCBI Official Symbol: | CRYGN�� |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | gamma-crystallin N |
| UniProt Protein Name: | Gamma-crystallin N |
| UniProt Synonym Protein Names: | Gamma-N-crystallin |
| Protein Family: | Gamma-crystallin |
| UniProt Gene Name: | CRYGN�� |
| UniProt Entry Name: | CRGN_HUMAN |
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