CD Antigens Recombinant Proteins

Human CRTAM Recombinant Protein (RPPB3266)

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SKU:
RPPB3266
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95727
Research Area:
CD Antigens

Description

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Product Name:Human CRTAM Recombinant Protein
Product Code:RPPB3266
Size:10µg
Species:Human
Target:CRTAM
Synonyms:Cytotoxic and Regulatory T Cell Molecule, Class I MHC Restricted T Cell Associated Molecule, Class-I MHC-Restricted T-Cell-Associated Molecule, Class-I MHC-Restricted T Cell Associated Molecule, Cytotoxic and Regulatory T-Cell Molecule, CD355 Antigen, CD355.
Source:Sf9 Insect cells
Physical Appearance:Sterilefiltered colorless solution.
Formulation: CRTAM protein solution (1mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% asdetermined by SDS-PAGE.
Amino Acid Sequence:SLTNHTETIT VEEGQTLTLKCVTSLRKNSS LQWLTPSGFT IFLNEYPALK NSKYQLLHHS ANQLSITVPN VTLQDEGVYK CLHYSDSVSTKEVKVIVLAT PFKPILEASV IRKQNGEEHV VLMCSTMRSK PPPQITWLLG NSMEVSGGTL HEFETDGKKCNTTSTLIIHT YGKNSTVDCI IRHRGLQGRK LVAPFRFEDL VTDEETASDA LERNSLSSQD PQQPTSTVSV TEDSSTSEIDKEEKEQTTQD PDLTTEANPQ YLGLARKKSG LEHHHHHH

Cytotoxic and Regulatory T Cell Molecule, also known as CRTAM belongs to the immunoglobulin superfamily which complies with the structural characteristics of the JAM family and is phylogenetically more closely related to nectin-like proteins. CRTAM is implicated in epithelial cell adhesion. Furthermore, CRTAM interacts with CADM1 as well as promotes natural killer (NK) cell cytotoxicity.

CRTAM produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 278 amino acids (18-287 a.a.) and having a molecular mass of 31.0kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).CRTAM is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CRTAM: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Apoptosis; Membrane protein, integralChromosomal Location of Human Ortholog: 11q24.1Cellular Component: integral to membrane; plasma membraneMolecular Function: receptor bindingBiological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; detection of tumor cell; activated T cell proliferation; detection of stimulus; cell recognition; positive regulation of natural killer cell mediated cytotoxicity; T cell mediated cytotoxicity; positive regulation of cytokine secretion
UniProt Protein Details:
NCBI Summary:The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
UniProt Code:O95727
NCBI GenInfo Identifier:755571554
NCBI Gene ID:56253
NCBI Accession:NP_001291711.1
UniProt Secondary Accession:O95727,Q59EI1, Q6IRX2
UniProt Related Accession:O95727
Molecular Weight:22,256 Da
NCBI Full Name:cytotoxic and regulatory T-cell molecule Isoform 2
NCBI Synonym Full Names:cytotoxic and regulatory T cell molecule
NCBI Official Symbol:CRTAM��
NCBI Official Synonym Symbols:CD355��
NCBI Protein Information:cytotoxic and regulatory T-cell molecule; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; class-I MHC-restricted T-cell-associated molecule
UniProt Protein Name:Cytotoxic and regulatory T-cell molecule
UniProt Synonym Protein Names:Class-I MHC-restricted T-cell-associated molecule; CD_antigen: CD355
Protein Family:Cytotoxic and regulatory T-cell molecule
UniProt Gene Name:CRTAM��
UniProt Entry Name:CRTAM_HUMAN
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