Human CRIP1 Recombinant Protein (RPPB3252)

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RPPB3252
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Product Name:Human CRIP1 Recombinant Protein
Product Code:RPPB3252
Size:20µg
Species:Human
Target:CRIP1
Synonyms:Cysteine-rich protein 1, Cysteine-rich heart protein, CRHP,hCRHP, Cysteine-rich intestinal protein, CRIP, CRP1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:CRIP1 protein solution (0.25mg/ml) containing 20mMTris-HCl(pH 8.0), 20% glycerol, 0.15M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSMPKCPKCNKEVYFAERV TSLGKDWHRP CLKCEKCGKT LTSGGHAEHE GKPYCNHPCY AAMFGPKGFG RGGAESHTFK

CRIP1also known as Cysteine-Rich Protein 1is a member to the LIM/doublezinc finger protein family, members of which comprise cysteine- and glycine-rich protein-1,rhombotin-1, rhombotin-2, and rhombotin-3. CRIP1 may be implicated in zinc absorption and also mayfunction as an intracellular zinc transport protein. Among the diseasesassociated with CRIP1 are situs inversus, and osteosarcoma.

CRIP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 100 amino acids (1-77 a.a) and having a molecular mass of 10.9kDa.CRIP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CRIP1: a LIM protein which is developmentally regulated in heart. May have a role in zinc absorption and may function as an intracellular zinc transport protein. The CRIP1 gene is hypomethylated in prostate cancer.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: cytoplasm

Molecular Function:AT DNA binding; DNA bending activity; peptide binding; zinc ion binding

Biological Process: cell proliferation; DNA damage response, signal transduction resulting in induction of apoptosis; heart development; immune response; regulation of gene expression; response to organic substance; response to zinc ion

NCBI Summary:Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]
UniProt Code:P50238
NCBI GenInfo Identifier:20981688
NCBI Gene ID:1396
NCBI Accession:P50238.3
UniProt Secondary Accession:P50238,Q13628, Q53XY7, Q96J34, H3BPI2,
UniProt Related Accession:P50238
Molecular Weight:8,533 Da
NCBI Full Name:Cysteine-rich protein 1
NCBI Synonym Full Names:cysteine rich protein 1
NCBI Official Symbol:CRIP1��
NCBI Official Synonym Symbols:CRHP; CRIP; CRP1; CRP-1��
NCBI Protein Information:cysteine-rich protein 1
UniProt Protein Name:Cysteine-rich protein 1
UniProt Synonym Protein Names:Cysteine-rich heart protein; CRHP; hCRHP; Cysteine-rich intestinal protein; CRIP
Protein Family:Cysteine-rich protein
UniProt Gene Name:CRIP1��
UniProt Entry Name:CRIP1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P50238
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