Human CREB3L2 Recombinant Protein (RPPB3249)

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SKU:
RPPB3249
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q70SY1

Description

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Product Name:Human CREB3L2 Recombinant Protein
Product Code:RPPB3249
Size:10µg
Species:Human
Target:CREB3L2
Synonyms:CAMPResponsive Element Binding Protein 3-Like 2, BBF2H7, CAMP-Responsive Element-BindingProtein 3-Like Protein 2, BBF2 Human Homolog On Chromosome 7, CyclicAMP-Responsive Element-Binding Protein 3-Like Protein 2, Basic TranscriptionFactor 2, B-ZIB Transcription Factor, FUS/BBF2H7 Protein, TCAG_1951439, CyclicAMP-responsive element-binding protein 3-like protein 2, cAMP-responsiveelement-binding protein 3-like protein 2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:CREB3L2 protein solution (0.25mg/ml) containing PBS (pH7.4), 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEVLESG EQGVLQWDRK LSELSEPGDG EALMYHTHFS ELLDEFSQNVLGQLLNDPFL SEKSVSMEVE PSPTSPAPLI QAEHSYSLCE EPRAQSPFTH ITSDSFNDDE VESEKWYLSTDFPSTSIKTE PITDEPPPGL VPSVTLTITA ISTPLEKEEPPLEMNTGVDS SCQTIIPKIK LEPHEVDQFL NFSPKEAPVD HLHLPPTPPSSHGSDSEGSL SPNPRLHPFS LPQTHSPSRA APRAPSALSS SPLLTAPHKL QGSGPLVLTE EEKRTLIAEGYPIPTKLPLS KSEEKALKKI RRKIKNKISA QESRRKKKEY MDSLEKKVES CSTENLELRKKVEVLENTNR TLLQQLQKLQ TLVMGKVSRT CKLAGTQTGT C

CAMP Responsive Element Binding Protein 3-Like 2, also known as CREB3L2belongs to the oasis bZIP transcription factor family. Members of this familyare able to dimerize however from homodimers only. CREB3L2 is a transcriptionalactivator. Translocations between CREB3L2 on chromosome 7 and the gene fused insarcoma on chromosome 16 can be found in some tumors. One disease which is associatedwith CREB3L2 is myxofibrosarcoma.

CREB3L2 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 401 amino acids (1-378 a.a) andhaving a molecular mass of 44kDa.CREB3L2 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:CREB3L2: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage. A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS. Belongs to the bZIP family. ATF subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: endoplasmic reticulum; nucleoplasm; nucleus

Biological Process: cartilage development; chondrocyte differentiation; positive regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q70SY1
NCBI GenInfo Identifier:296439387
NCBI Gene ID:64764
NCBI Accession:Q70SY1.3
UniProt Secondary Accession:Q70SY1,Q6P454, Q6ZMR6,
UniProt Related Accession:Q70SY1
Molecular Weight:57kDa
NCBI Full Name:Cyclic AMP-responsive element-binding protein 3-like protein 2
NCBI Synonym Full Names:cAMP responsive element binding protein 3 like 2
NCBI Official Symbol:CREB3L2��
NCBI Official Synonym Symbols:BBF2H7��
NCBI Protein Information:cyclic AMP-responsive element-binding protein 3-like protein 2
UniProt Protein Name:Cyclic AMP-responsive element-binding protein 3-like protein 2
UniProt Synonym Protein Names:BBF2 human homolog on chromosome 7
Protein Family:Cyclic AMP-responsive element-binding protein 3-like protein
UniProt Gene Name:CREB3L2��
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