Human CRCP Recombinant Protein (RPPB3247)

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SKU:
RPPB3247
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O75575

Description

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Product Name:Human CRCP Recombinant Protein
Product Code:RPPB3247
Size:20µg
Species:Human
Target:CRCP
Synonyms:CGRP receptor component protein, CGRP-RCP, RCP, RCP9, Calcitonin gene-related peptide-receptor component protein, RNA polymerase III subunit C9, DNA-directed RNA polymerase III subunit RPC9, HsC17, MGC111194.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CRCP solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEVKDANSAL LSNYEVFQLL TDLKEQRKES GKNKHSSGQQ NLNTITYETL KYISKTPCRH QSPEIVREFL TALKSHKLTK AEKLQLLNHR PVTAVEIQLM VEESEERLTE EQIEALLHTV TSILPAEPEA EQKKNTNSNV AMDEEDPA

CRCP is a ubiquitous coupling protein for the calcitonin gene-related peptide and adrenomedullin receptors. CRCP controls ligand sensitivity in several tissues and has DNA-directed RNA polymerase activity, catalytic activity and calcitonin receptor activity.

CRCP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 168 amino acids (1-148) and having a molecular mass of 19.0 kDa.The CRCP is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CGRP-RCP: an ubiquitous coupling protein for the calcitonin gene-related peptide (CGRP) and adrenomedullin receptors. Modulates ligand responsiveness in a variety of tissues. Two splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q11.21

Cellular Component: nucleoplasm; DNA-directed RNA polymerase III complex; plasma membrane; acrosome; cytosol

Molecular Function:calcitonin gene-related polypeptide receptor activity; DNA-directed RNA polymerase activity; nucleotide binding

Biological Process: transcription from RNA polymerase III promoter; transcription initiation from RNA polymerase III promoter; termination of RNA polymerase III transcription; neuropeptide signaling pathway; positive regulation of interferon type I production; innate immune response; gene expression; defense response to virus; RNA elongation from RNA polymerase III promoter

NCBI Summary:This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:O75575
NCBI GenInfo Identifier:20532033
NCBI Gene ID:27297
NCBI Accession:O75575.1
UniProt Secondary Accession:O75575,Q3KRA3, Q5HYF1, Q8IXL4, A8MUZ4, A8MW23, B2R4H4 B4E198,
UniProt Related Accession:O75575
Molecular Weight:148
NCBI Full Name:DNA-directed RNA polymerase III subunit RPC9
NCBI Synonym Full Names:CGRP receptor component
NCBI Official Symbol:CRCP��
NCBI Official Synonym Symbols:RCP; RCP9; CGRPRCP; CGRP-RCP��
NCBI Protein Information:DNA-directed RNA polymerase III subunit RPC9; RNA polymerase III subunit C9; CGRP-receptor component protein; calcitonin gene-related peptide-receptor component protein
UniProt Protein Name:DNA-directed RNA polymerase III subunit RPC9
UniProt Synonym Protein Names:Calcitonin gene-related peptide-receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; HsC17
Protein Family:DNA-directed RNA polymerase
UniProt Gene Name:CRCP��
UniProt Entry Name:RPC9_HUMAN
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