Human CRABP2 Recombinant Protein (RPPB3245)
- SKU:
- RPPB3245
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P29373
Description
| Product Name: | Human CRABP2 Recombinant Protein |
| Product Code: | RPPB3245 |
| Size: | 20µg |
| Species: | Human |
| Target: | CRABP2 |
| Synonyms: | RBP6, CRABP-II, CRABP2, RETINOIC ACID-BINDING PROTEIN CELLULAR TYPE II, Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CRABP2 protein solution contains 20mM Tris-HCl pH-8 and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT FYIKTSTTVR TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL LKGEGPKTSW TRELTNDGEL ILTMTADDVV CTRVYVRE |
CRABP2 NCBI Accession No: NP_001869 regulates the access of retinoic acid to the nuclear retinoic acid receptors. CRABP2 is involved in a regulatory feedback mechanism that controls the action of retinoic acid on cell differentiation.CRABP2 is involved in the conversion of vitamin A into its intracellular active form retinoic acid, which regulate the genes responsible for lipid metabolism and adipocyte differentiation. CRABP2 gene is located on chromosome 1q21-23 and this region has been linked with related disorders such as familial combined hyperlipidemia (FCHL) and type 2 diabetes mellitus.CRABP proteins are of low molecular weight having an important function in retinoic acid-mediated regulation of human skin growth and differentiation.
CRABP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 136 amino acids and having a molecular mass of 15.6 kDa. The CRABP2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CRABP2: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: nucleoplasm; endoplasmic reticulum; cytoplasm; cytosol Molecular Function:retinoid binding; retinoic acid binding; transporter activity; retinal binding; retinol binding Biological Process: embryonic forelimb morphogenesis; epidermis development; regulation of transcription, DNA-dependent; retinoic acid metabolic process; signal transduction; transmembrane transport |
| NCBI Summary: | This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010] |
| UniProt Code: | P29373 |
| NCBI GenInfo Identifier: | 132401 |
| NCBI Gene ID: | 1382 |
| NCBI Accession: | P29373.2 |
| UniProt Secondary Accession: | P29373,Q6ICN6, B2R4Z8, D3DVC5, F1T098, |
| UniProt Related Accession: | P29373 |
| Molecular Weight: | 138 |
| NCBI Full Name: | Cellular retinoic acid-binding protein 2 |
| NCBI Synonym Full Names: | cellular retinoic acid binding protein 2 |
| NCBI Official Symbol: | CRABP2�� |
| NCBI Official Synonym Symbols: | RBP6; CRABP-II�� |
| NCBI Protein Information: | cellular retinoic acid-binding protein 2; cellular retinoic acid-binding protein II |
| UniProt Protein Name: | Cellular retinoic acid-binding protein 2 |
| UniProt Synonym Protein Names: | Cellular retinoic acid-binding protein II; CRABP-II |
| Protein Family: | Cellular retinoic acid-binding protein |
| UniProt Gene Name: | CRABP2�� |
| UniProt Entry Name: | RABP2_HUMAN |
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