Human CPEB1 Recombinant Protein (RPPB3241)
- SKU:
- RPPB3241
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BZB8
Description
| Product Name: | Human CPEB1 Recombinant Protein |
| Product Code: | RPPB3241 |
| Size: | 20µg |
| Species: | Human |
| Target: | CPEB1 |
| Synonyms: | Cytoplasmic Polyadenylation Element Binding Protein 1, CPE-Binding Protein 1, CPE-BP1, HCPEB-1, CPEB, Cytoplasmic Polyadenylation Element-Binding Protein 1, CPEB-1, H-CEBP, CEBP, CPEB1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CPEB1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAFPLEE EAGRIKDCWD NQEAPALSTC SNANIFRRIN AILDNSLDFS RVCTTPINRG IHDHLPDFQD SEETVTSRML FPTSAQESSR GLPDANDLCL GLQSLSLTGW DRPWSTQDSD SSAQSSTHSV LSMLHNPLGN VLGKPPLSFL PLDPLGSDLV DKFPAPSVRG SRLDTRPILD SRSSSPSDSD TSGFSSGSDH LSDLISSLRI SPPLPFLSLS GGGPRDPLKM GVGSRMDQEQ AALAAVTPSP TSASKRWPGA SVWPSWDLLE APKDPFSIER EARLHRQAAA VNEATCTWSG QLPPRNYKNP IYSCKVFLGG VPWDITEAGL VNTFRVFGSL SVEWPGKDGK HPRCPPKGYV YLVFELEKSV RSLLQACSHD PLSPDGLSEY YFKMSSRRMR CKEVQVIPWV LADSNFVRSP SQRLDPSRTV FVGALHGMLN AEALAAILND LFGGVVYAGI DTDKHKYPIG SGRVTFNNQR SYLKAVSAAF VEIKTTKFTK KVQIDPYLED SLCHICSSQP GPFFCRDQVC FKYFCRSCWH WRHSMEGLRH HSPLMRNQKN RDSS |
Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) belongs to the cytoplasmic polyadenylation element (CPE) binding protein family, whose members regulate translation of cyclin B1 during embryonic cell divisions. The CPEB1 is a highly conserved protein which binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Analogous proteins in Xenopus and mouse function to stimulate cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation.
CPEB1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 584 amino acids (1-561) and having a molecular mass of 64.5 kDa.CPEB1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CPEB: cytoplasmic polyadenylation element binding protein 1. Binds to the protein CPE and drives its polyadenylation. Activated by the protein kinase AurA. Insulin and progesterone stimulate AurA-catalyzed phosphorylation of CPEB in oocytes. Neuronal CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. |
| UniProt Protein Details: | Protein type:Translation; RNA-binding Chromosomal Location of Human Ortholog: 15q25.2 Cellular Component: postsynaptic membrane; dendrite; postsynaptic density; cytoplasm; nucleus; cell junction Molecular Function:metal ion binding; translation repressor activity, nucleic acid binding; nucleotide binding Biological Process: synaptonemal complex assembly; cellular response to insulin stimulus; mRNA processing; regulation of neuronal synaptic plasticity |
| NCBI Summary: | This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| UniProt Code: | Q9BZB8 |
| NCBI GenInfo Identifier: | 74762720 |
| NCBI Gene ID: | 64506 |
| NCBI Accession: | Q9BZB8.1 |
| UniProt Secondary Accession: | Q9BZB8,P70166, P0C279, |
| UniProt Related Accession: | Q9BZB8 |
| Molecular Weight: | 53,635 Da |
| NCBI Full Name: | Cytoplasmic polyadenylation element-binding protein 1 |
| NCBI Synonym Full Names: | cytoplasmic polyadenylation element binding protein 1 |
| NCBI Official Symbol: | CPEB1�� |
| NCBI Official Synonym Symbols: | CPEB; CPEB-1; CPE-BP1; hCPEB-1�� |
| NCBI Protein Information: | cytoplasmic polyadenylation element-binding protein 1; CPE-binding protein 1 |
| UniProt Protein Name: | Cytoplasmic polyadenylation element-binding protein 1 |
| Protein Family: | C-phycoerythrin |
| UniProt Gene Name: | CPEB1�� |
| UniProt Entry Name: | CPEB1_HUMAN |
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