Enzymes Recombinant Proteins

Human CPA4 Recombinant Protein (RPPB1504)

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SKU:
RPPB1504
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UI42
Research Area:
Enzymes

Description

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Product Name:Human CPA4 Recombinant Protein
Product Code:RPPB1504
Size:10µg
Species:Human
Target:CPA4
Synonyms:Carboxypeptidase A4, Carboxypeptidase A3, CPA3, EC3.4.17.1, EC 3.4.17.-, EC 3.4.17, Carboxypeptidase A4, Carboxypeptidase A3.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CPA4protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10%glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:GQEKFFGDQV LRINVRNGDE ISKLSQLVNS NNLKLNFWKS PSSFNRPVDVLVPSVSLQAF KSFLRSQGLE YAVTIEDLQA LLDNEDDEMQ HNEGQERSSN NFNYGAYHSL EAIYHEMDNIAADFPDLARR VKIGHSFENR PMYVLKFSTG KGVRRPAVWL NAGIHSREWI SQATAIWTAR KIVSDYQRDPAITSILEKMD IFLLPVANPD GYVYTQTQNR LWRKTRSRNP GSSCIGADPN RNWNASFAGK GASDNPCSEVYHGPHANSEV EVKSVVDFIQ KHGNFKGFID LHSYSQLLMY PYGYSVKKAP DAEELDKVAR LAAKALASVSGTEYQVGPTC TTVYPASGSS IDWAYDNGIK FAFTFELRDT GTYGFLLPAN QIIPTAEETW LGLKTIMEHVRDNLYLEHHH HHH

Carboxypeptidase A4 (CPA4) belongs to the carboxypeptidase A/B subfamily, and it is located in a cluster with 3 other family members on chromosome 7. CPA4 is a secreted, zinc-dependent metallocarboxypeptidase, which removes the C-terminal amino acid from peptides having a free C-terminal carboxyl group. CPA4 is a metalloprotease which may be involved in the histone hyperacetylation pathway. CPA4 are synthesized as zymogens which are activated by proteolytic cleavage.

CPA4 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 413 amino acids (17-421a.a.) and having a molecular mass of 46.6kDa.CPA4 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CPA4: Metalloprotease that could be involved in the histone hyperacetylation pathway. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; EC 3.4.17.-; Secreted; Protease

Chromosomal Location of Human Ortholog: 7q32

Cellular Component: extracellular space

Molecular Function:metallocarboxypeptidase activity

NCBI Summary:This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UI42
NCBI GenInfo Identifier:61252703
NCBI Gene ID:51200
NCBI Accession:Q9UI42.2
UniProt Secondary Accession:Q9UI42,Q86UY9, B7Z576,
UniProt Related Accession:Q9UI42
Molecular Weight:43,570 Da
NCBI Full Name:Carboxypeptidase A4
NCBI Synonym Full Names:carboxypeptidase A4
NCBI Official Symbol:CPA4��
NCBI Official Synonym Symbols:CPA3��
NCBI Protein Information:carboxypeptidase A4
UniProt Protein Name:Carboxypeptidase A4
UniProt Synonym Protein Names:Carboxypeptidase A3
Protein Family:Carboxypeptidase
UniProt Gene Name:CPA4��
UniProt Entry Name:CBPA4_HUMAN
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