Human COMMD6 Recombinant Protein (RPPB3227)

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SKU:
RPPB3227
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q7Z4G1

Description

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Product Name:Human COMMD6 Recombinant Protein
Product Code:RPPB3227
Size:20µg
Species:Human
Target:COMMD6
Synonyms:COMM domain-containing protein 6, COMM Domain Containing 6, COMMD6, MSTP076, COMM domain-containing protein 6 isoform b, Acrg.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The COMMD6 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 20% glycerol, 0.15M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEASSEP PLDAKSDVTN QLVDFQWKLG MAVSSDTCRS LKYPYVAVML KVADHSGQVK TKCFEMTIPQ FQNFYRQFKE IAAVIETV

COMM Domain Containing (COMMD6) which is a part of the NF-kappa-B -inhibiting proteins, contains one COMM domain. COMMD6 down-regulates the activation of NF-kappa-B and inhibits TNF-induced NFKB1 activation.

COMMD6 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 108 amino acids (1-85) and having a molecular mass of 12kDa.COMMD6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:COMMD6: Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 13q22Cellular Component: cytoplasm; nucleusMolecular Function: NF-kappaB binding; protein bindingBiological Process: transcription, DNA-dependent; inhibition of NF-kappaB transcription factor
UniProt Protein Details:
NCBI Summary:COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]
UniProt Code:Q7Z4G1
NCBI GenInfo Identifier:565671780
NCBI Gene ID:170622
NCBI Accession:NP_001274323.1
UniProt Secondary Accession:Q7Z4G1,Q5TBK4, A6NF28, B7ZLN0
UniProt Related Accession:Q7Z4G1
Molecular Weight:10,908 Da
NCBI Full Name:COMM domain-containing protein 6 isoform c
NCBI Synonym Full Names:COMM domain containing 6
NCBI Official Symbol:COMMD6��
NCBI Official Synonym Symbols:Acrg��
NCBI Protein Information:COMM domain-containing protein 6; Acrg embryonic lethality minimal region ortholog
UniProt Protein Name:COMM domain-containing protein 6
UniProt Synonym Protein Names:
Protein Family:COMM domain-containing protein
UniProt Gene Name:COMMD6��
UniProt Entry Name:COMD6_HUMAN
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