Human COMMD1 Recombinant Protein (RPPB3226)

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SKU:
RPPB3226
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8N668

Description

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Product Name:Human COMMD1 Recombinant Protein
Product Code:RPPB3226
Size:10µg
Species:Human
Target:COMMD1
Synonyms:MURR1, C2orf5, COMMD1, Copper Metabolism Domain Containing 1, MGC27155.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:COMMD1 Human solution containing 20mM Tris pH-8, 0.1M NaCl & 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN

COMMD1 is accountable for inhibition of TNF-induced NF?B p50 and n facilitats of biliary copper excretion within hepatocytes. High expression of COMMD1 is localized in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. COMMD1 interacts directly with COMMD6 and ATP7B, and indirectly with I?B-Beta and COMMD7.

COMMD1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-190 a.a.) and having a molecular mass of 23.3 kDa. The COMMD1 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.
UniProt Protein Details:

Protein type:Inhibitor

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: Cul2-RING ubiquitin ligase complex; cytoplasm; cytoplasmic membrane-bound vesicle; early endosome; endosome membrane; nucleoplasm; nucleus; recycling endosome

Molecular Function:copper ion binding; identical protein binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity

Biological Process: copper ion homeostasis; Golgi to plasma membrane transport; inhibition of NF-kappaB transcription factor; plasma membrane to endosome transport; positive regulation of protein ubiquitination; protein transport; regulation of proteasomal ubiquitin-dependent protein catabolic process; transcription, DNA-dependent

NCBI Summary:COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]
UniProt Code:Q8N668
NCBI GenInfo Identifier:51316026
NCBI Gene ID:150684
NCBI Accession:Q8N668.1
UniProt Secondary Accession:Q8N668,Q96GS0, B4DFQ4,
UniProt Related Accession:Q8N668
Molecular Weight:17,665 Da
NCBI Full Name:COMM domain-containing protein 1
NCBI Synonym Full Names:copper metabolism domain containing 1
NCBI Official Symbol:COMMD1��
NCBI Official Synonym Symbols:MURR1; C2orf5��
NCBI Protein Information:COMM domain-containing protein 1
UniProt Protein Name:COMM domain-containing protein 1
UniProt Synonym Protein Names:Protein Murr1
Protein Family:COMM domain-containing protein
UniProt Gene Name:COMMD1��
UniProt Entry Name:COMD1_HUMAN
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