Immunology Recombinant Proteins

Human Collectin1/COLEC11 Recombinant Protein (RPES0824)

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SKU:
RPES0824
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology

Description

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Human Collectin1/COLEC11 Recombinant Protein

Collectin-11 is a secreted protein that belongs to the COLEC10/COLEC11 family. Collectin-11 contains one C-type lectin domain and one collagen-like domain. Collectins play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. Collectin-11 binds to various sugars including fucose and mannose, but does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. It has a higher affinity for fucose compared to mannose. Collectin-11 binds lipopolysaccharides (LPS). It also involved in fundamental development serving as a guidance cue for neural crest cell migration. Defects in Collectin-11 are the cause of 3MC syndrome type 2 (3MC2).

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