Cardiovascular Recombinant Proteins

Human COL8A1 Recombinant Protein (RPES0805)

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SKU:
RPES0805
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cardiovascular

Description

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Human COL8A1 Recombinant Protein

Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium of large blood vessels. The expression level can be up-regulated during vascular injury, in atherosclerosis and in diabetes. COL8A1 may have a role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.

Product Name:Human COL8A1 Recombinant Protein (RPES0805)
Product Code:RPES0805
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Collagen Alpha-1(VIII) Chain, Endothelial Collagen, Vastatin, COL8A1, C3orf7
Accession:P27658
Sequence:Gly28-Met744
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Collagen alpha-1(VIII) Chain is produced by our Mammalian expression system and the target gene encoding Gly28-Met744 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:71.6 kDa
AP Mol Mass:58-85 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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