Neurotrophins Recombinant Proteins

Human CNTFR Recombinant Protein (RPPB0133)

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SKU:
RPPB0133
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P26992
Research Area:
Neurotrophins

Description

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Product Name:Human CNTFR Recombinant Protein
Product Code:RPPB0133
Size:25µg
Species:Human
Target:CNTFR
Synonyms:CiliaryNeurotrophic Factor Receptor, CNTF Receptor Subunit Alpha, CNTFR-Alpha, CiliaryNeurotrophic Factor Receptor Subunit Alpha, Ciliary neurotrophic factorreceptor subunit alpha, CNTF receptor subunit alpha, CNTFR-alpha.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless clear solution.
Formulation:CNTFR protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MQRHSPQEAP HVQYERLGSD VTLPCGTANW DAAVTWRVNG TDLAPDLLNG SQLVLHGLELGHSGLYACFH RDSWHLRHQV LLHVGLPPRE PVLSCRSNTY PKGFYCSWHL PTPTYIPNTF NVTVLHGSKIMVCEKDPALK NRCHIRYMHL FSTIKYKVSI SVSNALGHNA TAITFDEFTI VKPDPPENVV ARPVPSNPRRLEVTWQTPST WPDPESFPLK FFLRYRPLIL DQWQHVELSD GTAHTITDAY AGKEYIIQVA AKDNEIGTWSDWSVAAHATP WTEEPRHLTT EAQAAETTTS TTSSLAPPPT TKICDPGELG S

Ciliary Neurotrophic Factor Receptor, also known as CNTFR is a member ofthe type I cytokine receptor family. CNTFR binds to CNTF. �The alpha subunitprovides the receptor specificity. Solenucleotide polymorphisms in CNTFR has been associated with variations in musclestrength, in addition to early onset of eating disorders.

CNTFR Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 341 amino acids (23-342 a.a) andhaving a molecular mass of 38.1kDa.CNTFR is fused to a 21 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:CNTFR: Binds to CNTF. The alpha subunit provides the receptor specificity. Belongs to the type I cytokine receptor family. Type 3 subfamily.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extrinsic to membrane

Molecular Function:cytokine binding; ciliary neurotrophic factor receptor activity; receptor binding

Biological Process: nervous system development; suckling behavior; positive regulation of cell proliferation; negative regulation of neuron apoptosis; signal transduction; sex differentiation

NCBI Summary:This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
UniProt Code:P26992
NCBI GenInfo Identifier:1352099
NCBI Gene ID:1271
NCBI Accession:P26992.2
UniProt Related Accession:P26992
Molecular Weight:40kDa
NCBI Full Name:Ciliary neurotrophic factor receptor subunit alpha
NCBI Synonym Full Names:ciliary neurotrophic factor receptor
NCBI Official Symbol:CNTFR��
NCBI Protein Information:ciliary neurotrophic factor receptor subunit alpha
UniProt Protein Name:Ciliary neurotrophic factor receptor subunit alpha
Protein Family:Ciliary neurotrophic factor receptor
UniProt Gene Name:CNTFR��
UniProt Entry Name:CNTFR_HUMAN
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