Neurotrophins Recombinant Proteins
Human CNTF Recombinant Protein (RPES3472)
- SKU:
- RPES3472
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Neurotrophins
Description
Human CNTF Recombinant Protein
Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. This protein has also been discovered to prevent motor nerve regeneration after damage. CNTF is highly conserved across species, with cross-species effects. CNTF proteins from both humans and rats have 83% homology in their amino acid sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. In their receptor complexes, all of these four-helix bundle cytokines include gp130 as a signal-transducing subunit. Due to their lack of a signal sequence, CNTFs such as FGF acidic, basic, and PD-ECGF (platelet-derived endothelial cell growth factor) are unable to be secreted via traditional secretion pathways. The mechanism underlying the release of CNTF is unknown. Human CNTF Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human CNTF Recombinant Protein (RPES3472) |
| Product Code: | RPES3472 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | Ciliary Neurotrophic Factor, CNTF |
| Accession: | P26441 |
| Sequence: | Ala2-Met200 |
| Activity: | Measured in a cell proliferation assay using TF?1 human erythroleukemic cells. The ED50 for this effect is 25 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Ciliary Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala2-Met200 is expressed. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 22.93 kDa |
| AP Mol Mass: | 25 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS,1mM Cysteine,PH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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