Human CNOT8 Recombinant Protein (RPPB3219)
- SKU:
- RPPB3219
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UFF9
Description
| Product Name: | Human CNOT8 Recombinant Protein |
| Product Code: | RPPB3219 |
| Size: | 20µg |
| Species: | Human |
| Target: | CNOT8 |
| Synonyms: | CCR4-NOT transcription complex subunit 8, CAF1, CALIF, hCAF1, POP2, CAF1-like protein, CAF2, CCR4-associated factor 8, Caf1b, CNOT8. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CNOT8 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPAALVE NSQVICEVWA SNLEEEMRKI REIVLSYSYI AMDTEFPGVV VRPIGEFRSS IDYQYQLLRC NVDLLKIIQL GLTFTNEKGE YPSGINTWQF NFKFNLTEDM YSQDSIDLLA NSGLQFQKHE EEGIDTLHFA ELLMTSGVVL CDNVKWLSFH SGYDFGYMVK LLTDSRLPEE EHEFFHILNL FFPSIYDVKY LMKSCKNLKG GLQEVADQLD LQRIGRQHQA GSDSLLTGMA FFRMKELFFE DSIDDAKYCG RLYGLGTGVA QKQNEDVDSA QEKMSILAII NNMQQ |
CCR4-NOT Transcription Complex, Subunit 8 (CNOT8) is a part of the CAF1 family. CNOT8 is a ubiquitous transcription factor necessary for a varied set of processes and functions as part of the CCR-NOT complex. The CCR4-NOT complex which functions as general transcription regulation complex binds BTG2 and holds CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8
CNOT8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (1-292) and having a molecular mass of 35.9 kDa.CNOT8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CNOT8: Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex. Belongs to the CAF1 family. |
| UniProt Protein Details: | Protein type:EC 3.1.13.4 Chromosomal Location of Human Ortholog: 5q31-q33 Cellular Component: intracellular; cytosol; nucleus; CCR4-NOT complex Molecular Function:protein binding; 3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; RNA binding; metal ion binding; transcription factor activity Biological Process: regulation of translation; negative regulation of cell proliferation; poly(A) tail shortening; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; gene expression; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay |
| UniProt Code: | Q9UFF9 |
| NCBI GenInfo Identifier: | 15213949 |
| NCBI Gene ID: | 9337 |
| NCBI Accession: | Q9UFF9.1 |
| UniProt Secondary Accession: | Q9UFF9,O95709, Q7Z521, Q9H6Y1, B0AZS3, B2RAR8, B7Z8R1 D3DQI8, |
| UniProt Related Accession: | Q9UFF9 |
| Molecular Weight: | 27,415 Da |
| NCBI Full Name: | CCR4-NOT transcription complex subunit 8 |
| NCBI Synonym Full Names: | CCR4-NOT transcription complex, subunit 8 |
| NCBI Official Symbol: | CNOT8�� |
| NCBI Official Synonym Symbols: | CAF1; POP2; CALIF; Caf1b; hCAF1�� |
| NCBI Protein Information: | CCR4-NOT transcription complex subunit 8; CAF2; CALIFp; CAF1-like protein; CCR4-associated factor 8; PGK promoter directed over production |
| UniProt Protein Name: | CCR4-NOT transcription complex subunit 8 |
| UniProt Synonym Protein Names: | CAF1-like protein; CALIFp; CAF2; CCR4-associated factor 8; Caf1b |
| Protein Family: | CCR4-NOT transcription complex |
| UniProt Gene Name: | CNOT8�� |
| UniProt Entry Name: | CNOT8_HUMAN |
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