Human CNN2 Recombinant Protein (RPPB3215)
- SKU:
- RPPB3215
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q99439
Description
| Product Name: | Human CNN2 Recombinant Protein |
| Product Code: | RPPB3215 |
| Size: | 20µg |
| Species: | Human |
| Target: | CNN2 |
| Synonyms: | Calponin 2, Calponin H2, Smooth Muscle, Neutral Calponin,calponin-2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CNN2protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15MNaCl, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSSTQFN KGPSYGLSAE VKNRLLSKYD PQKEAELRTW IEGLTGLSIGPDFQKGLKDG TILCTLMNKL QPGSVPKINR SMQNWHQLEN LSNFIKAMVS YGMNPVDLFE ANDLFESGNMTQVQVSLLAL AGKA |
Calponin 2 also known as CNN2 protein is capable of binding actin, calmodulin, troponin C, and tropomyosin, and also function in the structural organization of actin filaments. Furthermore, the interaction of CNN2 with actin inhibits the actomyosin Mg-ATPase activity. CNN2 takes part in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene.
CNN2 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 154 amino acids (1-131 a.a) andhaving a molecular mass of 16.9kDa.CNN2 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | calponin 2: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoskeleton; focal adhesion; intercellular junction; membrane; stress fiber Biological Process: cytoskeleton organization and biogenesis; regulation of actin filament-based process |
| NCBI Summary: | The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q99439 |
| NCBI GenInfo Identifier: | 6226844 |
| NCBI Gene ID: | 1265 |
| NCBI Accession: | Q99439.4 |
| UniProt Secondary Accession: | Q99439,Q92578, A5D8U8, A6NFI4, D6W5X9, |
| UniProt Related Accession: | Q99439 |
| Molecular Weight: | 29,500 Da |
| NCBI Full Name: | Calponin-2 |
| NCBI Synonym Full Names: | calponin 2 |
| NCBI Official Symbol: | CNN2�� |
| NCBI Protein Information: | calponin-2 |
| UniProt Protein Name: | Calponin-2 |
| UniProt Synonym Protein Names: | Calponin H2, smooth muscle; Neutral calponin |
| Protein Family: | Calponin |
| UniProt Gene Name: | CNN2�� |
| UniProt Entry Name: | CNN2_HUMAN |
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