Human CNN1 Recombinant Protein (RPPB3214)

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RPPB3214

Description

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Product Name:Human CNN1 Recombinant Protein
Product Code:RPPB3214
Size:20µg
Species:Human
Target:CNN1
Synonyms:Calponin 1 basic smooth muscle, Calponin H1 smooth muscle, SMCC, Basic calponin, Sm-Calp, calponin-1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CNN1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF MDGLKDGIIL CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND LFENTNHTQV QSTLLALASM AKTKGNKVNV GVKYAEKQER KFEPGKLREG RNIIGLQMGT NKFASQQGMT AYGTRRHLYD PKLGTDQPLD QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSALEH HHHHH�

CNN1 is a member of the calponin family. CNN1 is a thin filament-associated protein which is involved in the regulation and modulation of smooth muscle contraction. CNN1 is able to bind to actin, calmodulin, troponin C and tropomyosin. Prevention of actomyosin Mg-ATPase activity is a result of interaction between calponin and actin.

CNN1 Human Recombinant produced in E. coli is a single polypeptide chain containing 305 amino acids (1-297) and having a molecular mass of 34.2 kDa.CNN1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:calponin 1: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family.
UniProt Protein Details:

Protein type:Contractile; Motility/polarity/chemotaxis; Actin-binding; Myosin-binding

Chromosomal Location of Human Ortholog: 19p13.2-p13.1

Cellular Component: cytoskeleton; focal adhesion

Molecular Function:calmodulin binding; actin binding

Biological Process: regulation of smooth muscle contraction; actomyosin structure organization and biogenesis

UniProt Code:P51911
NCBI GenInfo Identifier:2829431
NCBI Gene ID:1264
NCBI Accession:P51911.2
UniProt Secondary Accession:P51911,O00638, Q15416, Q8IY93, Q99438, B2R868,
UniProt Related Accession:P51911
Molecular Weight:33,170 Da
NCBI Full Name:Calponin-1
NCBI Synonym Full Names:calponin 1, basic, smooth muscle
NCBI Official Symbol:CNN1��
NCBI Official Synonym Symbols:SMCC; Sm-Calp; HEL-S-14��
NCBI Protein Information:calponin-1; basic calponin; calponins, basic; calponin H1, smooth muscle; epididymis secretory protein Li 14
UniProt Protein Name:Calponin-1
UniProt Synonym Protein Names:Basic calponin; Calponin H1, smooth muscle
Protein Family:Calponin
UniProt Gene Name:CNN1��
UniProt Entry Name:CNN1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P51911
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