Human CLEC2D Recombinant Protein (RPPB3196)
- SKU:
- RPPB3196
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UHP7
Description
| Product Name: | Human CLEC2D Recombinant Protein |
| Product Code: | RPPB3196 |
| Size: | 20µg |
| Species: | Human |
| Target: | CLEC2D |
| Synonyms: | C-type lectin domain family 2 member D, CLAX1, LLT11, OCIL. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CLEC2D solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSRANCHQE PSVCLQAACP ESWIGFQRKC FYFSDDTKNW TSSQRFCDSQ DADLAQVESF QELNFLLRYK GPSDHWIGLS REQGQPWKWI NGTEWTRQFP ILGAGECAYL NDKGASSARH YTERKWICSK SDIHV |
C-type lectin domain family 2, also referred to CLEC2D, is a receptor for KLRB1 which protects target cells against natural killer cell-mediated lysis.It has been shown that CLEC2Dinhibits osteoclast formation and bone resorption. The protein controls the release of interferon-gamma and contains a transmembrane domain near the N-terminus likewisethe C-type lectin-like extracellular domain.
CLEC2D Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids (60-191 a.a.) and having a molecular mass of 17.7 kDa. CLEC2D is fused to a 23 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CLEC2D: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13 Cellular Component: cell surface; membrane; endoplasmic reticulum; integral to plasma membrane Molecular Function:transmembrane receptor activity; carbohydrate binding Biological Process: cell surface receptor linked signal transduction |
| NCBI Summary: | This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q9UHP7 |
| NCBI GenInfo Identifier: | 74753331 |
| NCBI Gene ID: | 29121 |
| NCBI Accession: | Q9UHP7.1 |
| UniProt Secondary Accession: | Q9UHP7,Q6YID5, Q8WUP7, Q9HD37, Q9HD38, D6CI39, D6CI40 D6CI41, |
| UniProt Related Accession: | Q9UHP7 |
| Molecular Weight: | 10,823 Da |
| NCBI Full Name: | C-type lectin domain family 2 member D |
| NCBI Synonym Full Names: | C-type lectin domain family 2, member D |
| NCBI Official Symbol: | CLEC2D�� |
| NCBI Official Synonym Symbols: | CLAX; LLT1; OCIL�� |
| NCBI Protein Information: | C-type lectin domain family 2 member D; LLT-1; C-type lectin related f; lectin-like transcript 1; lectin-like NK cell receptor; osteoclast inhibitory lectin; C-type lectin superfamily 2, member D |
| UniProt Protein Name: | C-type lectin domain family 2 member D |
| UniProt Synonym Protein Names: | Lectin-like NK cell receptor; Lectin-like transcript 1; LLT-1; Osteoclast inhibitory lectin |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC2D�� |
| UniProt Entry Name: | CLC2D_HUMAN |
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