Human CLEC1B Recombinant Protein (RPPB3193)
- SKU:
- RPPB3193
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9P126
Description
| Product Name: | Human CLEC1B Recombinant Protein |
| Product Code: | RPPB3193 |
| Size: | 5µg |
| Species: | Human |
| Target: | CLEC1B |
| Synonyms: | C-Type Lectin Domain Family 1 Member B, C-TypeLectin-Like Receptor 2, CLEC-2, CLEC2, C-Type Lectin Domain Family 1, Member B,1810061I13Rik, PRO1384, QDED721, CLEC2B, C-type lectindomain family 1 member B, C-type lectin-like receptor 2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CLEC1B protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPSVMQRNYLQGENENRTG TLQQLAKRFC QYVVKQSELK GTFKGHKCSP CDTNWRYYGD SCYGFFRHNL TWEESKQYCTDMNATLLKID NRNIVEYIKA RTHLIRWVGL SRQKSNEVWK WEDGSVISEN MFEFLEDGKG NMNCAYFHNGKMHPTFCENK HYLMCERKAG MTKVDQLPHH HHHH |
C-type Lectin Domain Family 1 Member B, also known as CLEC1B. NK-Natural killer cells express multiple calcium-dependent (C-type) lectin-like receptors, for instance CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), which interact with major histocompatibility complex class I molecules and either inhibit or else activate cytotoxicity and cytokine secretion. CLEC1B is a C-type lectin-like receptor which is expressed in myeloid cells as well as in NK cells.
CLEC1B Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 184 amino acids (55-229a.a) and having a molecular mass of 21.8kD (Molecular size on SDS-PAGE will appear at approximately 28-57kDa).CLEC1B is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CLEC1B: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.2 Cellular Component: integral to plasma membrane Molecular Function:protein binding; transmembrane receptor activity; carbohydrate binding Biological Process: cell surface receptor linked signal transduction; defense response; platelet formation |
| NCBI Summary: | Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | Q9P126 |
| NCBI GenInfo Identifier: | 134035066 |
| NCBI Gene ID: | 51266 |
| NCBI Accession: | Q9P126.2 |
| UniProt Secondary Accession: | Q9P126,Q6UWX7, Q8NHR6, |
| UniProt Related Accession: | Q9P126 |
| Molecular Weight: | 23,096 Da |
| NCBI Full Name: | C-type lectin domain family 1 member B |
| NCBI Synonym Full Names: | C-type lectin domain family 1, member B |
| NCBI Official Symbol: | CLEC1B�� |
| NCBI Official Synonym Symbols: | CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik�� |
| NCBI Protein Information: | C-type lectin domain family 1 member B; CLEC-2; C-type lectin-like receptor 2; C-type lectin-like receptor-2 |
| UniProt Protein Name: | C-type lectin domain family 1 member B |
| UniProt Synonym Protein Names: | C-type lectin-like receptor 2; CLEC-2 |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC1B�� |
| UniProt Entry Name: | CLC1B_HUMAN |
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