Human CIAPIN1 Recombinant Protein (RPPB3185)

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SKU:
RPPB3185
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q6FI81

Description

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Product Name:Human CIAPIN1 Recombinant Protein
Product Code:RPPB3185
Size:20µg
Species:Human
Target:CIAPIN1
Synonyms:DRE2, PRO0915, Anamorsin, Cytokine-induced apoptosis inhibitor 1, Fe-S cluster assembly protein DRE2 homolog, CIAPIN1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:CIAPIN1 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMADFGIS AGQFVAVVWD KSSPVEALKG LVDKLQALTG NEGRVSVENI KQLLQSAHKE SSFDIILSGL VPGSTTLHSA EILAEIARIL RPGGCLFLKE PVETAVDNNS KVKTASKLCS ALTLSGLVEV KELQREPLTP EEVQSVREHL GHESDNLLFV QITGKKPNFE VGSSRQLKLS ITKKSSPSVK PAVDPAAAKL WTLSANDMED DSMDLIDSDE LLDPEDLKKP DPASLRAASC GEGKKRKACK NCTCGLAEEL EKEKSREQMS SQPKSACGNC YLGDAFRCAS CPYLGMPAFK PGEKVLLSDS NLHDA

Anamorsin, ( CIAPIN) is a member of anamorsin family. CIAPIN mainly expressed in the cytoplasm of liver, pancreas and heart tissue cells and does not show any homology to known apoptosis regulatory molecules of the Bcl-2 or CASP families, or to signal transduction molecules. CIAPIN1 Expression is reliant on growth factor stimulation. It is a ubiquitously expressed protein, and when it is overexpressed, it grants apoptotic resistance.

CIAPIN1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 335 amino acids (1-312 a.a.) and having a molecular mass of 36kDa.CIAPIN1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CIAPIN1: May be required for the maturation of extramitochondrial Fe/S proteins. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. Belongs to the anamorsin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cytoplasm; nucleolus; nucleoplasm

Molecular Function:protein binding

Biological Process: iron-sulfur cluster assembly; negative regulation of apoptosis

NCBI Summary:CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]
UniProt Code:Q6FI81
NCBI GenInfo Identifier:57012667
NCBI Gene ID:57019
NCBI Accession:Q6FI81.2
UniProt Secondary Accession:Q6FI81,O75206, O75207, Q9H0W1, Q9P1L7, A8K8B6,
UniProt Related Accession:Q6FI81
Molecular Weight:32,213 Da
NCBI Full Name:Anamorsin
NCBI Synonym Full Names:cytokine induced apoptosis inhibitor 1
NCBI Official Symbol:CIAPIN1��
NCBI Official Synonym Symbols:DRE2; PRO0915; Anamorsin��
NCBI Protein Information:anamorsin
UniProt Protein Name:Anamorsin
UniProt Synonym Protein Names:Cytokine-induced apoptosis inhibitor 1
Protein Family:Anamorsin
UniProt Gene Name:CIAPIN1��
UniProt Entry Name:CPIN1_HUMAN
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