Human CIAO1 Recombinant Protein (RPPB3184)
- SKU:
- RPPB3184
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O76071
Description
| Product Name: | Human CIAO1 Recombinant Protein |
| Product Code: | RPPB3184 |
| Size: | 20µg |
| Species: | Human |
| Target: | CIAO1 |
| Synonyms: | CIA1, WDR39, Probable cytosolic iron-sulfur protein assembly protein CIAO1, WD repeat-containing protein 39, CIAO1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CIAO1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMKDSLVL LGRVPAHPDS RCWFLAWNPA GTLLASCGGD RRIRIWGTEG DSWICKSVLS EGHQRTVRKV AWSPCGNYLA SASFDATTCI WKKNQDDFEC VTTLEGHENE VKSVAWAPSG NLLATCSRDK SVWVWEVDEE DEYECVSVLN SHTQDVKHVV WHPSQELLAS ASYDDTVKLY REEEDDWVCC ATLEGHESTV WSLAFDPSGQ RLASCSDDRT VRIWRQYLPG NEQGVACSGS DPSWKCICTL SGFHSRTIYD IAWCQLTGAL ATACGDDAIR VFQEDPNSDP QQPTFSLTAH LHQAHSQDVN CVAWNPKEPG LLASCSDDGE VAFWKYQRPE GL |
CIAO1 is a vital component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. CIAO1 protein is required for the maturation of extra mitochondrial Fe/S proteins and seems to specifically modulate the trans-activation activity of WT1. CIAO1 participates in chromosome segregation as a part of the mitotic spindle-associated MMXD complex.
CIAO1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 362 amino acids (1-339a.a) and having a molecular mass of 40kDa. CIAO1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CIAO1: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. Belongs to the WD repeat CIA1 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q11.2 Biological Process: regulation of transcription from RNA polymerase II promoter; iron-sulfur cluster assembly; positive regulation of cell proliferation; chromosome segregation |
| UniProt Code: | O76071 |
| NCBI GenInfo Identifier: | 12229745 |
| NCBI Gene ID: | 9391 |
| NCBI Accession: | O76071.1 |
| UniProt Secondary Accession: | O76071,Q53FM5, A0MNN9, |
| UniProt Related Accession: | O76071 |
| Molecular Weight: | 339 |
| NCBI Full Name: | Probable cytosolic iron-sulfur protein assembly protein CIAO1 |
| NCBI Synonym Full Names: | cytosolic iron-sulfur assembly component 1 |
| NCBI Official Symbol: | CIAO1�� |
| NCBI Official Synonym Symbols: | CIA1; WDR39�� |
| NCBI Protein Information: | probable cytosolic iron-sulfur protein assembly protein CIAO1; WD40 protein Ciao1; WD repeat domain 39; WD repeat-containing protein 39; cytosolic iron-sulfur protein assembly 1 homolog |
| UniProt Protein Name: | Probable cytosolic iron-sulfur protein assembly protein CIAO1 |
| UniProt Synonym Protein Names: | WD repeat-containing protein 39 |
| Protein Family: | Probable cytosolic iron-sulfur protein assembly protein |
| UniProt Gene Name: | CIAO1�� |
| UniProt Entry Name: | CIAO1_HUMAN |
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