Human CHRNA3 Recombinant Protein (RPPB3182)
- SKU:
- RPPB3182
Description
| Product Name: | Human CHRNA3 Recombinant Protein |
| Product Code: | RPPB3182 |
| Size: | 20µg |
| Species: | Human |
| Target: | CHRNA3 |
| Synonyms: | Cholinergic Receptor, Nicotinic, Alpha 3 (Neuronal),Cholinergic Receptor, Nicotinic, Alpha Polypeptide 3, NACHRA3, LNCR2, PAOD2,Neuronal Nicotinic Acetylcholine Receptor, Alpha3 Subunit, NeuronalAcetylcholine Receptor Subunit Alpha-3, Acetylcholine Receptor, Alpha 3(Neuronal), Nicotinic, Neuronal acetylcholine receptor subunit alpha-3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CHRNA3 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MGSSEAEHRLFERLFEDYNE IIRPVANVSD PVIIHFEVSM SQLVKVDEVN QIMETNLWLK QIWNDYKLKW NPSDYGGAEFMRVPAQKIWK PDIVLYNNAV GDFQVDDKTK ALLKYTGEVT WIPPAIFKSS CKIDVTYFPF DYQNCTMKFGSWSYDKAKID LVLIGSSMNL KDYWESGEWA IIKAPGYKHD IKYNCCEEIY PDITYSLYIR RL |
Cholinergic Receptor Nicotinic Alpha 3, also known as CHRNA3 is part ofthe nicotinic acetylcholine receptor family. Proteins of this family formpentameric complexes comprised of both alpha & beta subunits. Furthermore,CHRNA3 is ligand-gated ions channel which prticipates in neurotransmission.CHRNA3 has been associated with an increased risk of smoking initiation as wellas an increased susceptibility to lung cancer.
CHRNA3 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 232 amino acids (32-240 a.a) andhaving a molecular mass of 27kDa.CHRNA3 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | nAChRA3: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 3/CHRNA3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated; Channel, cation Chromosomal Location of Human Ortholog: 15q24 Cellular Component: cell soma; dendrite; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic density Molecular Function:acetylcholine binding; acetylcholine receptor activity; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity Biological Process: behavioral response to nicotine; locomotory behavior; nervous system development; regulation of acetylcholine secretion; regulation of dendrite morphogenesis; regulation of excitatory postsynaptic membrane potential; regulation of membrane potential; regulation of smooth muscle contraction; signal transduction; synaptic transmission involved in micturition; synaptic transmission, cholinergic; transmembrane receptor protein tyrosine kinase activation (dimerization) Disease: Smoking As A Quantitative Trait Locus 3 |
| NCBI Summary: | This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009] |
| UniProt Code: | P32297 |
| NCBI GenInfo Identifier: | 254763435 |
| NCBI Gene ID: | 1136 |
| NCBI Accession: | P32297.4 |
| UniProt Secondary Accession: | P32297,Q15823, Q4KMN8, Q86U77, Q96RH3, Q99553, Q9BQ93 Q9BRR4, |
| UniProt Related Accession: | P32297 |
| Molecular Weight: | 55,637 Da |
| NCBI Full Name: | Neuronal acetylcholine receptor subunit alpha-3 |
| NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 3 subunit |
| NCBI Official Symbol: | CHRNA3�� |
| NCBI Official Synonym Symbols: | LNCR2; PAOD2; NACHRA3�� |
| NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-3 |
| UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-3 |
| Protein Family: | Neuronal acetylcholine receptor |
| UniProt Gene Name: | CHRNA3�� |
| UniProt Entry Name: | ACHA3_HUMAN |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Uniprot: |
P32297 |
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