Human CHRAC1 Recombinant Protein (RPPB3181)
- SKU:
- RPPB3181
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NRG0
Description
| Product Name: | Human CHRAC1 Recombinant Protein |
| Product Code: | RPPB3181 |
| Size: | 20µg |
| Species: | Human |
| Target: | CHRAC1 |
| Synonyms: | CHARC1, CHARC15, CHRAC-1, CHRAC-15, CHRAC15, YCL1, Chromatin accessibility complex protein 1, Chromatin accessibility complex 15 kDa protein, DNA polymerase epsilon subunit p15. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CHRAC1 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMADVVVG KDKGGEQRLI SLPLSRIRVI MKSSPEVSSI NQEALVLTAK ATELFVQCLA TYSYRHGSGK EKKVLTYSDL ANTAQQSETF QFLADILPKK ILASKYLKML KEEKREEDEE NDNDNESDHD EADS |
Chromatin Accessibility Complex 1 (CHRAC1) is a histone-fold protein which interacts with further histone-fold proteins to bind DNA in a sequence-independent mode. These histone-fold protein dimers combine within larger enzymatic complexes for DNA replication, transcription, and packaging.
CHRAC1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 154 amino acids (1-131 a.a.) and having a molecular mass of 17.1kDa. CHRAC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CHRAC1: Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: epsilon DNA polymerase complex; chromatin accessibility complex Molecular Function:DNA binding; sequence-specific DNA binding; protein heterodimerization activity; DNA-directed DNA polymerase activity Biological Process: chromatin remodeling |
| NCBI Summary: | CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004] |
| UniProt Code: | Q9NRG0 |
| NCBI GenInfo Identifier: | 22653683 |
| NCBI Gene ID: | 54108 |
| NCBI Accession: | Q9NRG0.1 |
| UniProt Related Accession: | Q9NRG0 |
| Molecular Weight: | 14,711 Da |
| NCBI Full Name: | Chromatin accessibility complex protein 1 |
| NCBI Synonym Full Names: | chromatin accessibility complex 1 |
| NCBI Official Symbol: | CHRAC1�� |
| NCBI Official Synonym Symbols: | YCL1; CHARC1; CHARC15; CHRAC-1; CHRAC15; CHRAC-15�� |
| NCBI Protein Information: | chromatin accessibility complex protein 1; DNA polymerase epsilon subunit p15; chromatin accessibility complex 15 kDa protein; histone-fold protein CHRAC15 |
| UniProt Protein Name: | Chromatin accessibility complex protein 1 |
| UniProt Synonym Protein Names: | Chromatin accessibility complex 15 kDa protein; CHRAC-15; HuCHRAC15; DNA polymerase epsilon subunit p15 |
| Protein Family: | Chromatin accessibility complex protein |
| UniProt Gene Name: | CHRAC1�� |
| UniProt Entry Name: | CHRC1_HUMAN |
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