Enzymes Recombinant Proteins
Human CHI3L2 Recombinant Protein (RPPB1492)
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- SKU:
- RPPB1492
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15782
- Research Area:
- Enzymes
Description
| Product Name: | Human CHI3L2 Recombinant Protein |
| Product Code: | RPPB1492 |
| Size: | 10µg |
| Species: | Human |
| Target: | CHI3L2 |
| Synonyms: | Chitinase 3-Like 2, Chondrocyte Protein 39, YKL-39, YKL39, Chitinase-3-Like Protein 2, CHIL2, CHI3L2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | CHI3L2 was filtered (0.4 �m) and lyophilized from 0.5mg/ml solution in 30mM acetate buffer, pH 4. |
| Solubility: | It is recommended to add 0.1M acetate buffer pH 4.0 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10?g/ml. In higher concentrations the solubility of this antigen is limited.CHI3L2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHASYKLVCYFTNW SQDRQEPGKF TPENIDPFLC SHLIYSFASI ENNKVIIKDK SEVMLYQTIN SLKTKNPKLK ILLSIGGYLF GSKGFHPMVD SSTSRLEFIN SIILFLRNHN FDGLDVSWIY PDQKENTHFT VLIHELAEAF QKDFTKSTKE RLLLTAGVSA GRQMIDNSYQ VEKLAKDLDF INLLSFDFHG SWEKPLITGH NSPLSKGWQD RGPSSYYNVE YAVGYWIHKG MPSEKVVMGI PTYGHSFTLA SAETTVGAPA SGPGAAGPIT ESSGFLAYYE ICQFLKGAKI TRLQDQQVPY AVKGNQWVGY DDVKSMETKV QFLKNLNLGG AMIWSIDMDD FTGKSCNQGP YPLVQAVKRS LGSL |
Chitinase 3-Like 2 (CHI3L2) is similar to bacterial chitinases but lacks chitinase activity. CHI3L2 protein is secreted and is involved in cartilage biogenesis. CHI3L2 is a lectin, which binds chitooligosaccharides and other glycans with high affinity.
CHI3L2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Tyr27-Leu390) containing 374 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 42.1kDa.
| UniProt Protein Function: | CHI3L2: Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: extracellular space Molecular Function:chitin binding; chitinase activity Biological Process: chitin catabolic process |
| NCBI Summary: | The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q15782 |
| NCBI GenInfo Identifier: | 13124005 |
| NCBI Gene ID: | 1117 |
| NCBI Accession: | Q15782.1 |
| UniProt Secondary Accession: | Q15782,Q15749, Q15783, Q5VUV7, Q96F97, A6NNY3, B4DPR7 |
| UniProt Related Accession: | Q15782 |
| Molecular Weight: | 42,508 Da |
| NCBI Full Name: | Chitinase-3-like protein 2 |
| NCBI Synonym Full Names: | chitinase 3 like 2 |
| NCBI Official Symbol: | CHI3L2�� |
| NCBI Official Synonym Symbols: | CHIL2; YKL39; YKL-39�� |
| NCBI Protein Information: | chitinase-3-like protein 2 |
| UniProt Protein Name: | Chitinase-3-like protein 2 |
| UniProt Synonym Protein Names: | Chondrocyte protein 39; YKL-39 |
| Protein Family: | Chitinase-3-like protein |
| UniProt Gene Name: | CHI3L2�� |
| UniProt Entry Name: | CH3L2_HUMAN |
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