Enzymes Recombinant Proteins

Human CHI3L2 Recombinant Protein (RPPB1492)

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SKU:
RPPB1492
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q15782
Research Area:
Enzymes

Description

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Product Name:Human CHI3L2 Recombinant Protein
Product Code:RPPB1492
Size:10µg
Species:Human
Target:CHI3L2
Synonyms:Chitinase 3-Like 2, Chondrocyte Protein 39, YKL-39, YKL39, Chitinase-3-Like Protein 2, CHIL2, CHI3L2.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:CHI3L2 was filtered (0.4 �m) and lyophilized from 0.5mg/ml solution in 30mM acetate buffer, pH 4.
Solubility:It is recommended to add 0.1M acetate buffer pH 4.0 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10?g/ml. In higher concentrations the solubility of this antigen is limited.CHI3L2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASYKLVCYFTNW SQDRQEPGKF TPENIDPFLC SHLIYSFASI ENNKVIIKDK SEVMLYQTIN SLKTKNPKLK ILLSIGGYLF GSKGFHPMVD SSTSRLEFIN SIILFLRNHN FDGLDVSWIY PDQKENTHFT VLIHELAEAF QKDFTKSTKE RLLLTAGVSA GRQMIDNSYQ VEKLAKDLDF INLLSFDFHG SWEKPLITGH NSPLSKGWQD RGPSSYYNVE YAVGYWIHKG MPSEKVVMGI PTYGHSFTLA SAETTVGAPA SGPGAAGPIT ESSGFLAYYE ICQFLKGAKI TRLQDQQVPY AVKGNQWVGY DDVKSMETKV QFLKNLNLGG AMIWSIDMDD FTGKSCNQGP YPLVQAVKRS LGSL

Chitinase 3-Like 2 (CHI3L2) is similar to bacterial chitinases but lacks chitinase activity. CHI3L2 protein is secreted and is involved in cartilage biogenesis. CHI3L2 is a lectin, which binds chitooligosaccharides and other glycans with high affinity.

CHI3L2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Tyr27-Leu390) containing 374 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 42.1kDa.

UniProt Protein Function:CHI3L2: Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: extracellular space

Molecular Function:chitin binding; chitinase activity

Biological Process: chitin catabolic process

NCBI Summary:The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Code:Q15782
NCBI GenInfo Identifier:13124005
NCBI Gene ID:1117
NCBI Accession:Q15782.1
UniProt Secondary Accession:Q15782,Q15749, Q15783, Q5VUV7, Q96F97, A6NNY3, B4DPR7
UniProt Related Accession:Q15782
Molecular Weight:42,508 Da
NCBI Full Name:Chitinase-3-like protein 2
NCBI Synonym Full Names:chitinase 3 like 2
NCBI Official Symbol:CHI3L2��
NCBI Official Synonym Symbols:CHIL2; YKL39; YKL-39��
NCBI Protein Information:chitinase-3-like protein 2
UniProt Protein Name:Chitinase-3-like protein 2
UniProt Synonym Protein Names:Chondrocyte protein 39; YKL-39
Protein Family:Chitinase-3-like protein
UniProt Gene Name:CHI3L2��
UniProt Entry Name:CH3L2_HUMAN
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