Human CHGB Recombinant Protein (RPPB3171)

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SKU:
RPPB3171
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P05060

Description

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Product Name:Human CHGB Recombinant Protein
Product Code:RPPB3171
Size:10µg
Species:Human
Target:CHGB
Synonyms:SCG1, Secretogranin 1, secretogranin B, CHGB, Sgl, CgB.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The CHGB protein 0.25mg/ml solution containing 20mM Tris-HCl pH-8, 0.15M NaCl & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MPVDNRNHNE GMVTRCIIEV LSNALSKSSA PPITPECRQV LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS RGEAGAPGEE DIQGPTKADT EKWAEGGGHS RERADEPQWS LYPSDSQVSE EVKTRHSEKS QREDEEEEEG ENYQKGERGE DSSEEKHLEE PGETQNAFLN ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG EEAGSQENHP QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG VQAPEDLEWE RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG YGEESEEERG LEPGKGRHHR GRGGEPRAYF MSDTREEKRF LGEGHHRVQE NQMDKARRHP QGAWKELDRN YLNYGEEGAP GKWQQQGDLQ DTKENREEAR FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD NMNDNFLEGE EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE DEKKELENLA AMDLELQKIA EKFSQRG

CHGB is a neuroendocrine secretory granule protein, that is the precursor for other biologically active peptides. CHGB is part of the chromogranin/secretogranin protein family and is expressed in the adrenal medulla, and in pheochromocytoma.

CHGB Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 677 amino acids (21-677 a.a.) and having a molecular mass of 78.4kDa. CHGB protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.

UniProt Protein Function:CHGB: a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20p12.3

Cellular Component: extracellular region; secretory granule

Molecular Function:protein binding; hormone activity

NCBI Summary:This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
UniProt Code:P05060
NCBI GenInfo Identifier:311033509
NCBI Gene ID:1114
NCBI Accession:P05060.2
UniProt Secondary Accession:P05060,Q59EU9, Q6IBS6, Q9BQV6, Q9UC25, Q9UJA6, A8K021
UniProt Related Accession:P05060
Molecular Weight:78kDa
NCBI Full Name:Secretogranin-1
NCBI Synonym Full Names:chromogranin B (secretogranin 1)
NCBI Official Symbol:CHGB��
NCBI Official Synonym Symbols:SCG1��
NCBI Protein Information:secretogranin-1; cgB; sgI; chromogranin-B; secretogranin B; secretogranin I
UniProt Protein Name:Secretogranin-1
UniProt Synonym Protein Names:Chromogranin-B; CgB; Secretogranin I; SgI
Protein Family:Secretogranin
UniProt Gene Name:CHGB��
UniProt Entry Name:SCG1_HUMAN
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