Human CHCHD3 Recombinant Protein (RPPB3164)

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SKU:
RPPB3164
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NX63

Description

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Product Name:Human CHCHD3 Recombinant Protein
Product Code:RPPB3164
Size:10µg
Species:Human
Target:CHCHD3
Synonyms:Regulatory Subunit 22, MINOS3, PPP1R22, MitochondrialInner Membrane Organizing System 3, Protein Phosphatase 1, Coiled-Coil-Helix-Coiled-Coil-HelixDomain-Containing Protein 3 Mitochondrial, Protein Phosphatase 1, RegulatorySubunit 22.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:CHCHD3 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGGTTST RRVTFEADEN ENITVVKGIR LSENVIDRMK ESSPSGSKSQRYSGAYGASV SDEELKRRVA EELALEQAKK ESEDQKRLKQ AKELDRERAA ANEQLTRAIL RERICSEEERAKAKHLARQL EEKDRVLKKQ DAFYKEQLAR LEERSSEFYR VTTEQYQKAA EEVEAKFKRY ESHPVCADLQ AKILQCYREN THQTLKCSALATQYMHCVNH AKQSMLEKGG

Coiled-coil-helix-coiled-coil-helixdomain containing 3 (CHCHD3), is a protein-coding gene. CHCHD3 is essential formaintenance of mitochondrial crista integrity and mitochondrial function. . Inaddition, CHCHD3 may perform as a scaffoldingprotein that stabilizes protein complexes involved in crista architecture andprotein import. CHCHD3 may also act as a transcription factor which binds tothe BAG1 promoter and represses BAG1 transcription. Lung cancer has beenassociated with CHCHD3.

CHCHD3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 250 amino acids (1-227 a.a) and having a molecular mass of 28.5kDa.CHCHD3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CHCHD3: May be a scaffolding protein that stabilizes protein complexes involved in maintaining mitochondrial crista architecture and protein import.
UniProt Protein Details:

Protein type:Mitochondrial

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion; nucleus

Molecular Function:phosphatase binding; protein binding; protein complex scaffold

Biological Process: cristae formation; inner mitochondrial membrane organization and biogenesis; mitochondrial fusion; negative regulation of transcription from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
UniProt Code:Q9NX63
NCBI GenInfo Identifier:62510520
NCBI Gene ID:54927
NCBI Accession:Q9NX63.1
UniProt Related Accession:Q9NX63
Molecular Weight:26,152 Da
NCBI Full Name:MICOS complex subunit MIC19
NCBI Synonym Full Names:coiled-coil-helix-coiled-coil-helix domain containing 3
NCBI Official Symbol:CHCHD3��
NCBI Official Synonym Symbols:Mic19; MINOS3; PPP1R22��
NCBI Protein Information:MICOS complex subunit MIC19
UniProt Protein Name:MICOS complex subunit MIC19
UniProt Synonym Protein Names:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3
UniProt Gene Name:CHCHD3��
UniProt Entry Name:MIC19_HUMAN
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