Hormones Recombinant Proteins

Human CGB Recombinant Protein (RPPB1268)

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SKU:
RPPB1268
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P01233
Research Area:
Hormones

Description

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Product Name:Human CGB Recombinant Protein
Product Code:RPPB1268
Size:20µg
Species:Human
Target:CGB
Synonyms:CGB3, CGB5, CGB7, CGB8, hCGB,� CG-beta, CGB.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:CGB protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSSKEPLRP RCRPINATLA VEKEGCPVCI TVNTTICAGY CPTMTRVLQG VLPALPQVVC NYRDVRFESI RLPGCPRGVN PVVSYAVALS CQCALCRRST TDCGGPKDHP LTCDDPRFQD SSSSKAPPPS LPSPSRLPGP SDTPILPQ

Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CGB is a member of the glycoprotein hormone beta chain family and is the beta 3 subunit of (CG). CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.

CGB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 168 amino acids (21-165 a.a.) and having a molecular mass of 17.9kDa. CGB is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CGB: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. Belongs to the glycoprotein hormones subunit beta family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 19q13.32

NCBI Summary:This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
UniProt Code:P01233
NCBI GenInfo Identifier:116184
NCBI Gene ID:94115
NCBI Accession:P01233.1
Molecular Weight:22kDa
NCBI Full Name:
NCBI Synonym Full Names:chorionic gonadotropin beta subunit 8
NCBI Official Symbol:CGB8��
NCBI Protein Information:chorionic gonadotropin, beta polypeptide 8
UniProt Protein Name:
Protein Family:Gonadotropin
UniProt Gene Name:
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