Human CETN2 Recombinant Protein (RPPB3152)
- SKU:
- RPPB3152
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P41208
Description
| Product Name: | Human CETN2 Recombinant Protein |
| Product Code: | RPPB3152 |
| Size: | 10µg |
| Species: | Human |
| Target: | CETN2 |
| Synonyms: | Centrin-2, Caltractin isoform 1, CETN2, CALT, CEN2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CETN2 solution (0.5 mg/ml) 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MASNFKKANM ASSSQRKRMS PKPELTEEQK QEIREAFDLF DADGTGTIDV KELKVAMRAL GFEPKKEEIK KMISEIDKEG TGKMNFGDFL TVMTQKMSEK DTKEEILKAF KLFDDDETGK ISFKNLKRVA KELGENLTDE ELQEMIDEAD RDGDGEVSEQ EFLRIMKKTS LY |
Caltractin (CETN2) is a member of a family of calcium-binding proteins and is a structural component of the centrosome. CETN2 has a role in nucleotide excision repair via association with xeroderma pigmentosum group C protein, suggesting possible coupling of cell division and nucleotide excision repair.
CETN2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 192 amino acids (1-172 a.a.) and having a molecular mass of 21.9kDa. The CETN2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CETN2: a calcium-binding proteins and is a structural component of the centrosome. Contains 4 EF-hand calcium-binding domains. Highly conserved from algae to humans. Its association with the centrosome suggests that it plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. |
| UniProt Protein Details: | Protein type:DNA repair, damage; Calcium-binding; Cell cycle regulation Chromosomal Location of Human Ortholog: Xq28 Cellular Component: centriole; centrosome; intracellular; cytosol; photoreceptor connecting cilium Molecular Function:protein binding; microtubule binding; G-protein beta/gamma-subunit binding; calcium ion binding; heterotrimeric G-protein binding Biological Process: mitosis; cell division; nucleotide-excision repair; organelle organization and biogenesis; centriole replication; spermatogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of cytokinesis |
| NCBI Summary: | Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41208 |
| NCBI GenInfo Identifier: | 729052 |
| NCBI Gene ID: | 1069 |
| NCBI Accession: | P41208.1 |
| UniProt Secondary Accession: | P41208,Q53XW1, B2R4T4, |
| UniProt Related Accession: | P41208 |
| Molecular Weight: | 172 |
| NCBI Full Name: | Centrin-2 |
| NCBI Synonym Full Names: | centrin, EF-hand protein, 2 |
| NCBI Official Symbol: | CETN2�� |
| NCBI Official Synonym Symbols: | CALT; CEN2�� |
| NCBI Protein Information: | centrin-2; caltractin (20kD calcium-binding protein) |
| UniProt Protein Name: | Centrin-2 |
| UniProt Synonym Protein Names: | Caltractin isoform 1 |
| Protein Family: | Centrin |
| UniProt Gene Name: | CETN2�� |
| UniProt Entry Name: | CETN2_HUMAN |
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