Human CETN1 Recombinant Protein (RPPB3151)
- SKU:
- RPPB3151
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q12798
Description
| Product Name: | Human CETN1 Recombinant Protein |
| Product Code: | RPPB3151 |
| Size: | 10µg |
| Species: | Human |
| Target: | CETN1 |
| Synonyms: | Centrin EF-hand protein 1, calcium binding protein, Caltractin isoform 2, CETN. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CETN1 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMASGFK KPSAASTGQK RKVAPKPELT EDQKQEVREA FDLFDVDGSG TIDAKELKVA MRALGFEPRK EEMKKMISEV DREGTGKISF NDFLAVMTQK MSEKDTKEEI LKAFRLFDDD ETGKISFKNL KRVANELGEN LTDEELQEMI DEADRDGDGE VNEEEFLRIM KKTSLY |
CETN1 is an EF-hand type Ca2+-binding protein. CETN1 is localized to the centrosome of interphase cells, and reorganizes the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. CETN1 has a vital part in the determination of centrosome position and isolation, and in the course of microtubule separating.
CETN1 Human Recombinant produced E. coli is a single polypeptide chain containing 221 amino acids (1-172) and having a molecular mass of 22.1kDa.CETN1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CETN1: Plays a fundamental role in microtubule-organizing center structure and function. Belongs to the centrin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 18p11.32 Cellular Component: centriole; spindle pole; centrosome; photoreceptor connecting cilium Molecular Function:protein binding; microtubule binding; G-protein beta/gamma-subunit binding; calcium ion binding; heterotrimeric G-protein binding Biological Process: mitosis; cell division |
| NCBI Summary: | The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q12798 |
| NCBI GenInfo Identifier: | 2493440 |
| NCBI Gene ID: | 1068 |
| NCBI Accession: | Q12798.1 |
| UniProt Secondary Accession: | Q12798,B2R536, |
| UniProt Related Accession: | Q12798 |
| Molecular Weight: | 172 |
| NCBI Full Name: | Centrin-1 |
| NCBI Synonym Full Names: | centrin, EF-hand protein, 1 |
| NCBI Official Symbol: | CETN1�� |
| NCBI Official Synonym Symbols: | CEN1; CETN�� |
| NCBI Protein Information: | centrin-1; caltractin; EF-hand protein; calcium binding protein |
| UniProt Protein Name: | Centrin-1 |
| UniProt Synonym Protein Names: | Caltractin isoform 2 |
| Protein Family: | Centrin |
| UniProt Gene Name: | CETN1�� |
| UniProt Entry Name: | CETN1_HUMAN |
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