Human CEACAM7 Recombinant Protein (RPPB3138)
- SKU:
- RPPB3138
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q14002
Description
| Product Name: | Human CEACAM7 Recombinant Protein |
| Product Code: | RPPB3138 |
| Size: | 10µg |
| Species: | Human |
| Target: | CEACAM7 |
| Synonyms: | CEA, CGM2, Carcinoembryonic antigen CGM2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CEACAM7 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSTNIDVVP FNVAEGKEVL LVVHNESQNL YGYNWYKGER VHANYRIIGY VKNISQENAP GPAHNGRETI YPNGTLLIQN VTHNDAGIYT LHVIKENLVN EEVTRQFYVF SEPPKPSITS NNFNPVENKD IVVLTCQPET QNTTYLWWVN NQSLLVSPRL LLSTDNRTLV LLSATKNDIG PYECEIQNPV GASRSDPVTL NVRYESVQAS |
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 (CEACAM7) is a member of the immunoglobulin superfamily, CEA family. CEACAM7 contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CEACAM7 is intensely down-regulated in colonic adenocarcinomas.
CEACAM7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 230 amino acids (36-242 a.a.) and having a molecular mass of 25.7kDa.CEACAM7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CEACAM7: Belongs to the immunoglobulin superfamily. CEA family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Immunoglobulin superfamily; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: plasma membrane; integral to membrane |
| NCBI Summary: | This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| UniProt Code: | Q14002 |
| NCBI GenInfo Identifier: | 5901930 |
| NCBI Gene ID: | 1087 |
| NCBI Accession: | NP_008821.1 |
| UniProt Secondary Accession: | Q14002,O15148, O15149, Q0VAC1, Q13983, Q9UPJ2, A8K848 |
| UniProt Related Accession: | Q14002 |
| Molecular Weight: | 19,031 Da |
| NCBI Full Name: | carcinoembryonic antigen-related cell adhesion molecule 7 |
| NCBI Synonym Full Names: | carcinoembryonic antigen related cell adhesion molecule 7 |
| NCBI Official Symbol: | CEACAM7�� |
| NCBI Official Synonym Symbols: | CGM2�� |
| NCBI Protein Information: | carcinoembryonic antigen-related cell adhesion molecule 7 |
| UniProt Protein Name: | Carcinoembryonic antigen-related cell adhesion molecule 7 |
| UniProt Synonym Protein Names: | Carcinoembryonic antigen CGM2 |
| Protein Family: | Carcinoembryonic antigen-related cell adhesion molecule |
| UniProt Gene Name: | CEACAM7�� |
| UniProt Entry Name: | CEAM7_HUMAN |
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