Human CEACAM3 Recombinant Protein (RPPB3135)
- SKU:
- RPPB3135
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P40198
Description
| Product Name: | Human CEACAM3 Recombinant Protein |
| Product Code: | RPPB3135 |
| Size: | 10µg |
| Species: | Human |
| Target: | CEACAM3 |
| Synonyms: | Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3, Carcinoembryonic Antigen CGM1, CD66d Antigen , CD66D, CGM1, Carcinoembryonic Antigen Gene Family Member 1, Nonspecific Cross-Reacting Antigen, W264, W282, CEA, CEACAM3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CEACAM3 protein solution (0.25mg/ml) containing Phosphate buffered saline (pH7.4) and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSKLTIESM PLSVAEGKEV LLLVHNLPQH LFGYSWYKGE RVDGNSLIVG YVIGTQQATP GAAYSGRETI YTNASLLIQN VTQNDIGFYT LQVIKSDLVN EEATGQFHVY QENAPGLPVG AVAG |
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3, also known asCEACAM3, is a member of the immunoglobulin super family. The genes in thisfamily encode cell adhesion proteins, which are expressed at higher levels intumorous tissues rather than in normal tissues. CEACAM3 plays a significant partin the clearance of pathogens through the innate immune system. In addition,CEACAM3 is accountable for RAC1 stimulation in the course of pathogenphagocytosis.
CEACAM3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 144 amino acids (35-155 a.a) and having a molecular mass of 15.5kDa.CEACAM3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CEACAM3: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation. CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. Belongs to the immunoglobulin superfamily. CEA family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: integral to membrane |
| NCBI Summary: | This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013] |
| UniProt Code: | P40198 |
| NCBI GenInfo Identifier: | 218511974 |
| NCBI Gene ID: | 1084 |
| NCBI Accession: | P40198.2 |
| UniProt Related Accession: | P40198 |
| Molecular Weight: | |
| NCBI Full Name: | Carcinoembryonic antigen-related cell adhesion molecule 3 |
| NCBI Synonym Full Names: | carcinoembryonic antigen related cell adhesion molecule 3 |
| NCBI Official Symbol: | CEACAM3�� |
| NCBI Official Synonym Symbols: | CEA; CGM1; W264; W282; CD66D�� |
| NCBI Protein Information: | carcinoembryonic antigen-related cell adhesion molecule 3 |
| UniProt Protein Name: | Carcinoembryonic antigen-related cell adhesion molecule 3 |
| UniProt Synonym Protein Names: | Carcinoembryonic antigen CGM1; CD_antigen: CD66d |
| UniProt Gene Name: | CEACAM3�� |
| UniProt Entry Name: | CEAM3_HUMAN |
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