Cell Cycle Recombinant Proteins

Human CDKN1B Recombinant Protein (RPES1523)

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RPES1523

Description

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Human CDKN1B Recombinant Protein

Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.

Product Name:Human CDKN1B Recombinant Protein (RPES1523)
Product Code:RPES1523
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Cyclin-Dependent Kinase Inhibitor 1B, Cyclin-Dependent Kinase Inhibitor p27, p27Kip1, CDKN1B, KIP1
Accession:P46527
Sequence:Met 1-Thr198
Fusion tag:N-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Cyclin-Dependent Kinase Inhibitor 1B is produced by our E.coli expression system and the target gene encoding Met1-Thr198 is expressed with a 6His tag at the N-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:24.2 kDa
AP Mol Mass:27 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Cycle
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