Human CDK5RAP3 Recombinant Protein (RPPB3003)

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RPPB3003

Description

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Product Name:Human CDK5RAP3 Recombinant Protein
Product Code:RPPB3003
Size:20µg
Species:Human
Target:CDK5RAP3
Synonyms:CDK5 Regulatory Subunit Associated Protein 3, LXXLL/Leucine-Zipper-Containing ARF-Binding Protein, LXXLL/Leucine-Zipper-Containing ARFbinding Protein, Ischemic Heart CDK5 Activator-Binding Protein C53, IC53, LZAP, CDK5 Regulatory Subunit Associated Protein IC53-2, CDK5 Regulatory Subunit-Associated Protein 3, CDK5 Activator-Binding Protein C53, Protein HSF-27, OK/SW-Cl.114, HSF-27, MST016, PP1553, C53, CDK5RAP3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CDK5RAP3 protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEDHQHVPID IQTSKLLDWL VDRRHCSLKW QSLVLTIREK INAAIQDMPE SEEIAQLLSG SYIHYFHCLR ILDLLKGTEA STKNIFGRYS SQRMKDWQEI IALYEKDNTY LVELSSLLVR NVNYEIPSLK KQIAKCQQLQ QEYSRKEEEC QAGAAEMREQ FYHSCKQYGI TGENVRGELL ALVKDLPSQL AEIGAAAQQS LGEAIDVYQA SVGFVCESPT EQVLPMLRFV QKRGNSTVYE WRTGTEPSVV ERPHLEELPE QVAEDAIDWG DFGVEAVSEG TDSGISAEAA GIDWGIFPES DSKDPGGDGI DWGDDAVALQ ITVLEAGTQA PEGVARGPDA LTLLEYTETR NQFLDELMEL EIFLAQRAVE LSEEADVLSV SQFQLAPAIL QGQTKEKMVT MVSVLEDLIG KLTSLQLQHL FMILASPRYV DRVTEFLQQK LKQSQLLALK KELMVQKQQE ALEEQAALEP KLDLLLEKTK ELQKLIEADI SKRYSGRPVN LMGTSL

CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) is a potential regulator of CDK5 activity via its interaction with CDK5R. Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is comprised of a catalytic subunit, CDK5, nad an activating subunit, p25NCK5A. CDK5RAP3 binds to p25NCK5A and hence may be involved in neuronal differentiation.

CDK5RAP3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 526 amino acids (1-506 a.a) and having a molecular mass of 59kDa.CDK5RAP3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CDK5RAP3: Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1. Belongs to the CDK5RAP3 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: protein complex; membrane; cytoplasm; nucleolus; endomembrane system; nucleus

Molecular Function:cyclin binding; protein binding; protein kinase binding

Biological Process: cell proliferation; regulation of neuron differentiation; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; regulation of mitotic cell cycle; positive regulation of transcription from RNA polymerase II promoter; brain development; regulation of cyclin-dependent protein kinase activity

NCBI Summary:This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
UniProt Code:Q96JB5
NCBI GenInfo Identifier:32129444
NCBI Gene ID:80279
NCBI Accession:Q96JB5.2
UniProt Secondary Accession:Q96JB5,Q53FA2, Q9H3F8, Q9H8G0, Q9HBR9, B7Z6N4, D3DTU1 D3DTU2, F5H3I5,
UniProt Related Accession:Q96JB5
Molecular Weight:506
NCBI Full Name:CDK5 regulatory subunit-associated protein 3
NCBI Synonym Full Names:CDK5 regulatory subunit associated protein 3
NCBI Official Symbol:CDK5RAP3��
NCBI Official Synonym Symbols:C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114��
NCBI Protein Information:CDK5 regulatory subunit-associated protein 3; CDK5 regulatory subunit associated protein IC53-2; ischemic heart CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARFbinding protein
UniProt Protein Name:CDK5 regulatory subunit-associated protein 3
UniProt Synonym Protein Names:CDK5 activator-binding protein C53; Protein HSF-27
Protein Family:CDK5RAP3-like protein
UniProt Gene Name:CDK5RAP3��
UniProt Entry Name:CK5P3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96JB5
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