Human CDK5R1 / Cyclin-dependent kinase 5 activator 1 ELISA Kit

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SKU:
HUFI01459
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q15078
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
CDK5R1, Cyclin-dependent kinase 5 activator 1, CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit, CDK5R, NCK5A
Reactivity:
Human
Research Area:
Cell Biology

Description

Human CDK5R1 / Cyclin-dependent kinase 5 activator 1 ELISA Kit

CDK5R1 / Cyclin-dependent kinase 5 activator 1 is a neuron-specific activator of CDK5, which is required for proper development of the central nervous system. CDK5R1 / Cyclin-dependent kinase 5 activator 1 is proteolytically cleaved by calpain, which results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. Accumulation of CDK5R1 / Cyclin-dependent kinase 5 activator 1 correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

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