Enzymes Recombinant Proteins
Human CDK2AP2 Recombinant Protein (RPPB2456)
- SKU:
- RPPB2456
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75956
- Research Area:
- Enzymes
Description
| Product Name: | Human CDK2AP2 Recombinant Protein |
| Product Code: | RPPB2456 |
| Size: | 20µg |
| Species: | Human |
| Target: | CDK2AP2 |
| Synonyms: | Cyclin-dependent kinase 2-associated protein 2, CDK2-associated protein 2, DOC-1-related protein, DOC-1R, CDK2AP2, DOC1R, p14. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | CDK2AP2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSYKPIA PAPSSTPGSS TPGPGTPVPT GSVPSPSGSV PGAGAPFRPL FNDFGPPSMG YVQAMKPPGA QGSQSTYTDL LSVIEEMGKE IRPTYAGSKS AMERLKRGII HARALVRECL AETERNART |
Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2) is a member of the CDK2AP family. CDK2-associated protein is assumed to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. CDK2AP2 is implicated in the regulation of self-renewal of stem cells during early embryogenesis. CDK2AP2 is a regulator for self-renewal of mESCs (mouse embryonic stem cells) under permissive conditions, and cell survival during differentiation of the mESCs into terminally differentiated cell types.
CDK2AP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 149 amino acids (1-126 a.a) and having a molecular mass of 15.5kDa.CDK2AP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CDK2AP2: Belongs to the CDK2AP family.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 11q13 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012] |
| UniProt Code: | O75956 |
| NCBI GenInfo Identifier: | 6014990 |
| NCBI Gene ID: | 10263 |
| NCBI Accession: | O75956.1 |
| UniProt Secondary Accession: | O75956 |
| UniProt Related Accession: | O75956 |
| Molecular Weight: | 13,101 Da |
| NCBI Full Name: | Cyclin-dependent kinase 2-associated protein 2 |
| NCBI Synonym Full Names: | cyclin dependent kinase 2 associated protein 2 |
| NCBI Official Symbol: | CDK2AP2�� |
| NCBI Official Synonym Symbols: | p14; DOC-1R�� |
| NCBI Protein Information: | cyclin-dependent kinase 2-associated protein 2 |
| UniProt Protein Name: | Cyclin-dependent kinase 2-associated protein 2 |
| UniProt Synonym Protein Names: | DOC-1-related protein; DOC-1R |
| Protein Family: | Cyclin-dependent kinase 2-associated protein |
| UniProt Gene Name: | CDK2AP2�� |
| UniProt Entry Name: | CDKA2_HUMAN |
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