Human CDK12 / CrkRS ELISA Kit

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SKU:
HUFI02005
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q9NYV4
Sensitivity:
46.875pg/ml
Range:
78.125-5000pg/ml
ELISA Type:
Sandwich
Synonyms:
CDK12, Cell division protein kinase 12, hCDK12, Cdc2-related kinase, arginine, serine-rich, CrkRS, Cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7,
Reactivity:
Human
Research Area:
Epigenetics and Nuclear Signaling

Description

Human CDK12 / CrkRS ELISA

CDK12 / CrkRS is a highly specific and potent cell cycle inhibitor, which regulates the transition from G1 to S phase in the cell cycle by inhibiting Rb phosphorylation. CDK12 / CrkRS is found in the promoter region of Tumor protein p53 (TP53), indicating a possible role in cancer. CDK12 / CrkRS can cause resistance to chemotherapy drugs (such as Doxorubicin) by protecting cells from apoptosis after treatment. Diseases associated with CDK12 include Adenosquamous Prostate Carcinoma and Lung Cancer.

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