CD Antigens Recombinant Proteins

Human CD8B Recombinant Protein (RPPB3028)

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SKU:
RPPB3028
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P10966
Research Area:
CD Antigens

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human CD8B Recombinant Protein
Product Code:RPPB3028
Size:20µg
Species:Human
Target:CD8B
Synonyms:T Lymphocyte Surface Glycoprotein Beta Chain, CD8 Antigen, Beta Polypeptide 1 (P37), CD8b Molecule, CD8b Antigen, T-Cell Surface Glycoprotein CD8 Beta Chain, CD8B1, LYT3, LY3, LEU2, P37.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The CD8B solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSSDSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SP

CD8B encodes the CD8 beta chain isoforms of the CD8 antigen. CD8 is a cell surface glycoprotein which facilitates efficient cell-cell interactions within the immune system and is located on most cytotoxic T lymphocytes. The T-cell receptor on the T lymphocyte and the co-receptor CD8 antigen identify antigens exposed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional co-receptor is either a heterodimer composed of one alpha and one beta chain or a homodimer composed of two alpha chains. Both alpha and beta chains share substantial homology to immunoglobulin variable light chains.�

CD8B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 172 amino acids (22-170) and having a molecular mass of 19.2 kDa. CD8B is fused to a 23 amino acid His-tag at N-terminus.

UniProt Protein Function:CD8B: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: T cell receptor complex; integral to plasma membrane; early endosome membrane; plasma membrane; extracellular region; external side of plasma membrane

Molecular Function:protein binding; MHC class I protein binding; coreceptor activity

Biological Process: regulation of immune response; T cell activation; viral reproduction; immune response; regulation of defense response to virus by virus; transmembrane receptor protein tyrosine kinase signaling pathway

NCBI Summary:The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
UniProt Code:P10966
NCBI GenInfo Identifier:116032
NCBI Gene ID:926
NCBI Accession:P10966.1
UniProt Secondary Accession:P10966,P14860, P14861, Q15980, Q496E0, Q496E1, Q496E2 Q9UDB4, Q9UDB5, Q9UDB6, Q9UDB7, Q9UDB8,
UniProt Related Accession:P10966
Molecular Weight:210
NCBI Full Name:T-cell surface glycoprotein CD8 beta chain
NCBI Synonym Full Names:CD8b molecule
NCBI Official Symbol:CD8B��
NCBI Official Synonym Symbols:LY3; P37; LEU2; LYT3; CD8B1��
NCBI Protein Information:T-cell surface glycoprotein CD8 beta chain; CD8 antigen, beta polypeptide 1 (p37); T lymphocyte surface glycoprotein beta chain
UniProt Protein Name:T-cell surface glycoprotein CD8 beta chain
UniProt Synonym Protein Names:CD_antigen: CD8b
Protein Family:T-cell surface glycoprotein
UniProt Gene Name:CD8B��
UniProt Entry Name:CD8B_HUMAN
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