Human CD80/B7 Recombinant Protein (RPES3616)
- SKU:
- RPES3616
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
system_update_altDatasheet
Human CD80/B7 Recombinant Protein
Cluster of Differentiation 80; also called B7-1; is a member of cell surface immunoglobulin superfamily which plays key; yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells; macrophages and dendritic cells.
| Product Name: | Human CD80/B7 Recombinant Protein (RPES3616) |
| Product Code: | RPES3616 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | CD80, Activation B7-1 antigen, B7, BB1, CD28LG1, CD28LGB7-1 antigen, T-lymphocyte activation antigen CD80,B7-1,B7.1,CD28LG,LAB7 |
| Accession: | NP_005182.1 |
| Sequence: | Val35-Asn242 |
| Fusion tag: | C-6His |
| Activity: | Immobilized Human CD28-Fc(Cat: PKSH032211) at 10µg/ml(100 ?l/well) can bind Human B7-1 -His. The ED50 of Human B7-1 -His is 14.3 ug/mL |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Activation B7-1 antigen is produced by our Mammalian expression system and the target gene encoding Val35-Asn242 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 24.7 kDa |
| AP Mol Mass: | 38-60 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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