CD Antigens Recombinant Proteins

Human CD72 Recombinant Protein (RPPB3090)

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SKU:
RPPB3090
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P21854
Research Area:
CD Antigens

Description

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Product Name:Human CD72 Recombinant Protein
Product Code:RPPB3090
Size:10µg
Species:Human
Target:CD72
Synonyms:CD72, CD72b, LYB2, B-cell differentiation antigen CD72, Lyb-2.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CD72 protein solution (0.5mg/ml) contains 50mM Tris-HCl buffer (pH6.8), 0.2M NaCl, 2mM DTT and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:ADPRYLQVSQ QLQQTNRVLE VTNSSLRQQL RLKITQLGQS AEDLQGSRRE LAQSQEALQVEQRAHQAAEG QLQACQADRQ KTKETLQSEE QQRRALEQKL SNMENRLKPF FTCGSADTCCPSGWIMHQKS CFYISLTSKN WQESQKQCET LSSKLATFSE IYPQSHSYYF LNSLLPNGGSGNSYWTGLSS NKDWKLTDDT QRTRTYAQSS KCNKVHKTWS WWTLESESCR SSLPYICEMTAFRFPDLEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSHEDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKALPAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPENNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH

CD72 antigen is a member of the type II integral membrane glycoproteins which includes other related cell surface moleculaes such as the asialoglycoprotein receptors, CD23 and the Kupffer cell recpeotr. The exposure of B cells to CD72 antibodies activates a variety of signalling pathways and can induce MHC class II expression and B cell proliferation. CD72 antigen is expressed on all cells of B cell lineage with the exception of plasma cells and weakly on human tissue macrophages.

CD72 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 485 amino acids (117-359a.a.) and having a molecular mass of 55.3kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).CD72 is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CD72: Plays a role in B-cell proliferation and differentiation.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:protein binding; receptor binding

Biological Process: cell adhesion

UniProt Code:P21854
NCBI GenInfo Identifier:116029
NCBI Gene ID:971
NCBI Accession:P21854.1
UniProt Related Accession:P21854
Molecular Weight:40,220 Da
NCBI Full Name:B-cell differentiation antigen CD72
NCBI Synonym Full Names:CD72 molecule
NCBI Official Symbol:CD72��
NCBI Official Synonym Symbols:LYB2; CD72b��
NCBI Protein Information:B-cell differentiation antigen CD72
UniProt Protein Name:B-cell differentiation antigen CD72
UniProt Synonym Protein Names:Lyb-2; CD_antigen: CD72
Protein Family:B-cell differentiation antigen
UniProt Gene Name:CD72��
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