Human CD62L Monoclonal Antibody (Biotin Conjugated) [DREG56](AGEL0223)

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SKU:
AGEL0223
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
DREG56
Conjugation:
Biotin
Applications:
FC

Description

system_update_altDatasheet
Antibody Name:Human CD62L Monoclonal Antibody (Biotin Conjugated)
Antibody Code:AGEL0223
Size:100µg
Clone:DREG56
Synonyms:L-selectin, Sell, CD62 antigen-like family member L, LAM-1, LECAM1, Lymph node homing receptor, Ly-22, CD62L, Lnhr, Ly22
Host Species:Mouse
Species Reactivity:Human
Applications:FC
Concentration:1mg/mL
Isotype:IgG1
Conjugation:Biotin
Applications:FC
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:PBS with 0.05% Proclin300, 1% BSA
Storage:Keep as concentrated solution.Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Gene ID:6402
Uniprot:P14151
Background:CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naïve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells.
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