Immune Checkpoint Recombinant Proteins
Human CD47 Recombinant Protein (mFc-His Tag) (HDPT0008)
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- SKU:
- HDPT0008
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immune Checkpoint
Description
Human CD47 Recombinant Protein (mFc-His Tag)
| Description: | Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. |
| Product name: | Human CD47 Recombinant Protein (mFc-His Tag) |
| Synonyms: | CD47, MER6, IAP, OA3 |
| Type: | protein |
| Size: | 50 µg |
| Name: | CD47 |
| Origin: | Human |
| Source: | HEK293 |
| Protein Type: | Recombinant |
| Application: | ELISA |
| Purity: | > 95% |
| Purification: | affinity purification |
| Format: | Lyophilized |
| Conjugate: | C-Mouse Fc and 6×His tag |
| Storage: | Store at -80°C for 12 months (Avoid repeated freezing and thawing) |
| Usage: | Research use only |
| Buffer: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. |
| Reconstitution: | Reconstitute with deionized water |
| Sequence: | CD47（Gln19-Gln141）+CD47（Val198-Ala207）+CD47（Ser257-Gly268）+mFc（Pro99-Lys330）+6×His tag |
| Gene ID: | 961 |
| Uniprot: | Q08722 |
| Molecular Weight: | 60 kDa |
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