Immunology Recombinant Proteins
Human CD46 Recombinant Protein (RPES5245)
- SKU:
- RPES5245
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
Human CD46 Recombinant Protein
CD46/MCP has cofactor activity for the inactivation of complement components C3b and C4b by serum factor I, which protects autologous cells against complement-mediated injury. The protein CD46/MCP may play a role in the fusion of the spermatozoa with the ovum during fertilization. CD46/MCP also acts as a costimulatory molecule for T-cells, prompting the transformation of CD4+ cells into T-regulatory 1 cells. CD46/MCP gene mutations have been linked with hemolytic uremic syndrome. The pathways regulated by CD46/MCP include the Immune response Lectin-induced complement system and NF-kappaB Signaling. Human CD46 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human CD46 Recombinant Protein (RPES5245) |
| Product Code: | RPES5245 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Membrane Cofactor Protein, TLX, Trophoblast Leukocyte Common Antigen, CD46, MCP, MIC10,AHUS2,TLX,TRA2.10 |
| Accession: | P15529 |
| Sequence: | Cys35-Asp328 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human CD46 is produced by our Mammalian expression system and the target gene encoding Cys35-Asp328 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 33.8 kDa |
| AP Mol Mass: | 55 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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